© James St. John · CC BY 2.0 · Commons
Panther cap
Toxic🐾Pantherpilz · (Amanita pantherina)
Amanita family (Amanitaceae)
Description
An olive-brown to grey-brown cap dotted with white, wart-like patches and a distinct ring on the stem identify the panther cap, which fruits from June to November mostly in deciduous and mixed woodland and belongs to the amanita family. It contains ibotenic acid, muscimol, muscazone and small amounts of muscarine – compounds of interest in ethnomycology and neuroscience research, but they make this mushroom unsuitable for consumption under any circumstances. It is considered more toxic than the better-known fly agaric and is frequently confused with the edible blusher, a mix-up that regularly causes severe poisoning. Symptoms include nausea, dilated pupils, confusion and seizures, and can progress to respiratory failure. This is NOT an edible mushroom; if ingestion is suspected, contact emergency poison control immediately.
🌿 Risk of confusion — read before wild-harvesting!
POISONOUS, more so than the fly agaric and potentially fatal. Contains ibotenic acid and muscimol; poisoning (pantherina syndrome) causes nausea, vomiting, dilated pupils, confusion, agitation or intoxication, seizures within a few minutes to about two hours (rarely longer) and can progress to coma and respiratory arrest. High risk of confusion with the edible blusher (A.
Historical documentation only — do NOT use
These internal applications are historically documented. This plant is highly toxic — self-treatment can cause severe poisoning or death. For documentation only, explicitly NOT a recommendation.
Historical-ethnomycological context: the panther cap is grouped with the fly agaric among the ibotenic-acid/muscimol-bearing Amanita species studied in research on the intoxicating mushrooms of northern Eurasia (e.g. Siberian shamanism, where the fly agaric in particular played a role). This is purely historical-documentary context and NOT a usage guide; the mushroom is poisonous.
Pharmacological context: the constituents ibotenic acid (a glutamate/NMDA receptor agonist) and muscimol (a potent GABA-A receptor agonist) have long been studied in basic neuropharmacology; ibotenic acid is used in the laboratory to produce targeted lesions of nervous tissue. This describes the mechanisms and research use of the isolated compounds, not consumption of the mushroom.
POISONOUS, more so than the fly agaric and potentially fatal. Contains ibotenic acid and muscimol; poisoning (pantherina syndrome) causes nausea, vomiting, dilated pupils, confusion, agitation or intoxication, seizures within a few minutes to about two hours (rarely longer) and can progress to coma and respiratory arrest. High risk of confusion with the edible blusher (A. rubescens) and the grey spotted amanita. NOT an edible mushroom. If poisoning is suspected, contact a poison control centre / emergency services immediately. Do not ingest.
Harvested part: fruiting body
- Ibotensäure / Ibotenic acidOther
Isoxazole compound; non-selective glutamate and NMDA receptor agonist, partly decarboxylates to muscimol on drying.
- MuscimolOther
Potent GABA-A receptor agonist; the main sedative-psychoactive component, formed from ibotenic acid.
- Muscazon / MuscazoneOther
Photochemical conversion product of ibotenic acid, present in small amounts, weakly active.
- Muscarin / MuscarineAlkaloid
Largely absent in Amanita pantherina (traces at most); the namesake of muscarinic receptors but of no relevant toxicological role here.
- [4]MonographIbotenic Acid — an overview, ScienceDirect Topics(accessed: 2026-05-31)
- [6]MonographAmanita muscaria, Amanita pantherina and others (IPCS INCHEM PIM G026)(accessed: 2026-05-31)
- [8]MonographCliniTox Giftpflanzen — Amanita pantherina var. pantherina (DC. ex Fr.) Krombh.: stark giftig ++ (Institut für Veterinärpharmakologie und -toxikologie, Universität Zürich)(accessed: 2026-08-10)
- [1]WikipediaAmanita pantherina — Wikipedia (English)(accessed: 2026-05-31)
- [2]WikipediaPantherpilz — Wikipedia (Deutsch)(accessed: 2026-05-31)
- [3]WikipediaPantherina-Syndrom — Wikipedia (Deutsch)(accessed: 2026-05-31)
- [5]WikipediaMuscimol — Wikipedia (English)(accessed: 2026-05-31)
- [7]CommonsFile:Amanita pantherina (panther cap mushroom).jpg — Wikimedia Commons(accessed: 2026-05-31)