© Franz Eugen Köhler, Köhler's Medizinal-Pflanzen · Public domain · Commons
Peppermint
Caution🐾Pfefferminze · (Mentha × piperita)
Mint family (Lamiaceae)
Description
Peppermint is a hybrid species of mint, a cross between watermint and spearmint. Indigenous to Europe and the Middle East, the plant is now widely spread and cultivated in many regions of the world. It is occasionally found in the wild with its parent species.
Critical drug interactions with:
Antazida, H2-Rezeptor-Antagonisten, Protonenpumpenhemmer (PPI)
Peppermint leaf infusion (Kommission E positive) for relief of digestive complaints including flatulence, dyspepsia and spasmodic gastrointestinal symptoms.
Preparation & dosage
INFUSION (Kommission E / EMA traditional): 1.5–3 g of finely cut dried peppermint leaf in 150 ml boiling water, covered, steep 10 min, strain. Three times daily, freshly prepared, preferably between meals or before eating. Daily dose 3–6 g. Indications: dyspepsia, bloating, flatulence, spasmodic gastrointestinal complaints. Children 4–11 yrs: 1–2 g per cup, max. 3× daily. Do not use in reflux / heartburn / hiatal hernia — menthol relaxes the lower oesophageal sphincter. Maximum self-treatment duration 4 weeks without medical evaluation.
- Dry amount
- 1.5–3 g
- Doses per day
- 3×
- Max duration
- 4 weeks
⚠ Age restriction: ≥ 4 years — Not recommended for children under 4. Children 4–11 years with reduced dose (1–2 g). Adult dose from age 12.
Peppermint oil in enteric-coated capsules (EMA well-established use) — leading herbal preparation for irritable bowel syndrome with solid clinical evidence.
Preparation & dosage
PEPPERMINT OIL — ENTERIC-COATED CAPSULES (EMA well-established use): 0.2–0.4 ml peppermint oil in enteric-coated capsules, 3× daily, swallowed whole (!) with a large glass of water, 30–60 min before meals. Daily dose 0.6–1.2 ml. Children 8–11 yrs: 0.2 ml 3× daily. Indication: irritable bowel syndrome (IBS — spasmodic abdominal pain, meteorism, altered bowel habits). Enteric coating is mandatory — menthol released in the stomach causes heartburn, belching and oesophageal spasm. Do NOT take with antacids, H2-blockers or proton pump inhibitors — premature coating dissolution. Contraindicated in gallstones, cholangitis, achlorhydria, severe liver disease.
- Liquid amount
- 0.2–0.4 ml
- Doses per day
- 3×
- Max duration
- 12 weeks
⚠ Age restriction: ≥ 8 years — Contraindicated under 2 years (menthol-induced apnoea, laryngospasm). Not recommended under 8 years. Children 8–11 yrs: 0.2 ml capsule only.
External application of 10 % peppermint oil on forehead and temples for mild tension headache — analgesic effect clinically documented (EMA well-established use).
Preparation & dosage
EXTERNAL USE — TENSION HEADACHE (EMA well-established): 10 % peppermint oil in ethanol applied liberally to forehead and temples. One application, repeat after 15 min if needed, maximum three times. Do not apply to eyes, mucous membranes or wounds. Not for face or nose of infants/toddlers under 2 (apnoea risk). Demonstrated analgesic action via cutaneous cold reflexes (TRPM8 activation) and reduced scalp circulation — clinically comparable to 500 mg paracetamol.
- Doses per day
- 3×
⚠ Age restriction: ≥ 18 years — Per EMA for this specific indication adults 18+ only. General external use from age 12 on small skin areas possible.
Steam inhalation with peppermint oil for symptomatic relief of cold symptoms and upper respiratory tract catarrh (EMA traditional use).
Preparation & dosage
STEAM INHALATION (EMA traditional): 2–4 drops (0.08–0.16 ml) peppermint oil in a bowl of hot (not boiling, ~65–70 °C) water. Cover head with towel, close eyes, breathe deeply through the nose for 5–10 min. Up to 3× daily. Maintain at least 30 cm from the water to avoid scalding. Indication: symptomatic relief of colds, nasal congestion, upper respiratory tract catarrh. Alternative: 1–2 drops on a handkerchief and inhale. NOT for bronchial asthma or hypersensitive airways.
- Liquid amount
- 0.08–0.16 ml
- Doses per day
- 3×
- Max duration
- 2 weeks
⚠ Age restriction: ≥ 12 years — Contraindicated under 2 years. Not recommended under 12 years. From age 12 with reduced dose (1–2 drops).
Traditional peppermint tincture for dyspepsia and spasmodic gastrointestinal complaints — alternative to tea for precise dosing.
Preparation & dosage
TINCTURE (DER 1:5 in 45–70 % ethanol): 2–4 ml (40–80 drops) 3× daily, diluted in water, between meals. Daily dose 6–12 ml. Traditional use for dyspepsia, spasmodic gastrointestinal complaints and nervous stomach upsets. Action based on menthol (spasmolytic) and flavonoids (cholagogue). Due to ethanol: not in alcohol dependence, liver disease, pregnancy, lactation or children. Do not use in heartburn / reflux.
- Liquid amount
- 2–4 ml
- Doses per day
- 3×
- Max duration
- 4 weeks
Folk peppermint compress for muscle tension, tired legs and mild joint complaints — cooling-analgesic effect through menthol.
Preparation & dosage
COMPRESS (folk use): 5–10 g dried peppermint leaves in 500 ml boiling water, steep 15 min, strain, cool to ~40 °C. Soak a linen cloth or gauze bandage, squeeze gently, apply to the affected area (tense neck, tired legs, sore joints) for 10–15 min. Twice daily. Volatile menthol vapour provides local analgesic and cooling effect via TRPM8 stimulation. Do NOT apply to irritated, broken skin or mucous membranes.
- Dry amount
- 5–10 g
- Doses per day
- 2×
- Max duration
- 2 weeks
Fresh and dried peppermint leaves as culinary herb in salads, sauces, beverages and spice mixes — versatile in the kitchen and used worldwide.
Preparation & dosage
KITCHEN: Fresh or dried peppermint leaves are a versatile culinary herb. Fresh leaves: tabbouleh, mint sauce with lamb (British traditional), mojito, mint lemonade, summer salads, yoghurt dips (tzatziki variant), fruit salads, iced teas. Dried leaves: herbal tea blends, marinades, spice mixes (Moroccan ras el hanout). Culinary amounts have no therapeutic effect — safe as a spice. Peppermint propagates easily from cuttings and grows in any moist pot. Note: caution with open-ground planting — the plant spreads via runners and can crowd out other herbs.
IMPORTANT — MENTHOL WARNINGS: Never apply peppermint oil or leaves undiluted to the face, nose or mucous membranes of infants and toddlers under 2 years — acute apnoea and laryngospasm risk (life-threatening). Enteric-coated peppermint oil capsules must not be taken with antacids, H2-blockers or proton pump inhibitors — premature coating dissolution causes oesophageal spasm and heartburn. In gallbladder disease (gallstones, cholangitis) oral peppermint oil is contraindicated — menthol increases bile flow. Menthol may be contraindicated in pre-existing epilepsy or known seizure history. Peppermint (leaf and oil) relaxes the lower oesophageal sphincter — avoid in reflux / heartburn / hiatal hernia. Self-medication limit: max. 4 weeks without medical evaluation. ASPCA classification (accessed 2026-08-10): toxic to dogs, cats and horses.
Per EMA, the safety of peppermint leaf and peppermint oil at therapeutic doses during pregnancy is not sufficiently established — use not recommended. Culinary use of small amounts of fresh leaves is considered safe. Peppermint oil capsules and concentrated tinctures should be avoided in pregnancy.
Therapeutic menthol doses not recommended during lactation — menthol passes into breast milk and may cause breathing problems or colic in the infant. Culinary use of small amounts of leaves is considered safe. Peppermint oil must not be applied to nipples or breasts (menthol inhalation by newborn).
Peppermint leaf tea: not recommended under 4 years; 4–11 years with reduced dose (1–2 g). Peppermint oil internal: not recommended under 8 years; contraindicated under 2 years (apnoea, laryngospasm from menthol). Inhalation: not recommended under 12 years; contraindicated under 2 years. Menthol products (ointments, rubs) NOT on face, nose or chest of young children — apnoea risk. Contraindicated with seizure history.
Drug interactions
Antazida, H2-Rezeptor-Antagonisten, Protonenpumpenhemmer (PPI)
These drugs raise gastric pH and may cause premature dissolution of enteric-coated peppermint oil capsules. Menthol released in the stomach leads to oesophageal spasm, heartburn and reduced therapeutic efficacy. Avoid concomitant intake — minimum 2-hour interval.
CYP3A4-Substrate (z. B. Amlodipin, Simvastatin, Cyclosporin, Midazolam)
Menthol and other peppermint oil components inhibit CYP3A4 in vitro and, to a lesser extent, CYP1A2 and CYP2C19. Concomitant use with CYP3A4-metabolised drugs may increase plasma concentrations. Clinical relevance at normal doses is low, but caution with narrow therapeutic index CYP3A4 substrates.
Ciclosporin (Cyclosporin A)
Case reports and in-vitro studies indicate inhibition of CYP3A4 and P-glycoprotein by menthol, potentially raising ciclosporin plasma levels. In transplant patients on ciclosporin immunosuppression: close plasma level monitoring and avoid therapeutic doses of peppermint oil.
Antidiabetika (Insulin, Sulfonylharnstoffe, Metformin)
Peppermint and menthol may influence blood glucose levels in experimental models. Not clinically established as significant, but monitor blood glucose closely when taking intensive antidiabetic therapy, especially at higher peppermint oil doses.
Contraindications
- Hypersensitivity to peppermint, menthol or other Lamiaceae.
- Gallstones, cholangitis, biliary obstruction, achlorhydria — peppermint oil oral use contraindicated (menthol increases bile flow).
- Severe liver disease — impaired menthol metabolism; oral use only after medical consultation.
- Gastro-oesophageal reflux, heartburn, hiatal hernia — peppermint (leaf and oil) relaxes the lower oesophageal sphincter and worsens symptoms.
- Children under 2 years: peppermint oil and menthol-containing products contraindicated (apnoea, laryngospasm — life-threatening).
- Known epilepsy or seizure history: menthol may lower seizure threshold — contraindicated.
Harvested part: leaves (before flowering)
- Time of day:
- On dry, sunny mornings (ideal harvest: approx. 9–11 am), once dew has evaporated and before midday heat sets in. Essential oil content is highest at this time — essential oils accumulate in the leaf oil glands through photosynthetic activity and are maximally concentrated in the morning.
- Drying:
- HARVEST: Cut shoot tips and leaves before or at the onset of flowering (bud stage, July) — menthol content is highest at this stage because the plant has not yet invested resources in flower formation. Cut stems 5–10 cm above the ground (promotes regrowth). Harvest only healthy, clean leaves — leaves with powdery mildew (mint is susceptible) must be discarded completely. DRYING: Loosely tie small bundles and hang upside down in shade with good air circulation, max. 35–40 °C — higher temperatures cause volatile oil loss. Alternatively: spread single leaves in a single layer on drying racks. Drying time: 5–10 days depending on humidity. Dry when leaves crackle and crumble easily. STORAGE: Airtight in dark jars or tins, dry and cool. Use within 12 months — aroma loss accelerates significantly after that.
- Storage:
- 12 months — Airtight, dark, cool and dry. If colour changes (yellowing) or menthol scent weakens, check quality and discard if necessary.
- Time of day:
- Shoot tips with young leaves in spring (May–June) before flowering, and again after cutting back in September for a second flush. Morning harvest preferred.
- Drying:
- FRESH USE (kitchen and culinary): Young shoots and leaves are best used immediately after harvest — aromatics are most intense in the first 2–3 hours after cutting. For long-term preservation: freeze single layers of leaves on baking paper, then store in freezer bags up to 6 months (gentler than drying — essential oils largely preserved). For herb pesto, mint oil or tincture: process fresh — menthol yield is significantly higher from fresh material than dried drug.
- Storage:
- 6 months — Fresh: in refrigerator in damp cloth up to 3 days. Frozen: up to 6 months in freezer bags.
- Menthol (l-Menthol)Essential oilContent: 35-55 % (im äth. Öl)Leaf
Principal active compound and main constituent of peppermint essential oil. Monoterpene alcohol with spasmolytic (smooth muscle, calcium channel blockade), local anaesthetic (Na+ channel blockade), cooling (TRPM8 activation) and weak antibacterial activity. Responsible for the characteristic cooling effect on skin and mucous membranes. Apnoea risk in infants/toddlers when applied to the face.
- Menthon und IsomenthonEssential oilContent: 14-32 % (im äth. Öl)Leaf
Monoterpene ketones — principal co-constituents of menthol in the essential oil. Menthone contributes to the spasmolytic action and characteristic mint aroma. At high concentrations potentially irritating to mucous membranes — responsible for stronger effect of neat oil versus diluted preparations.
- MenthylacetatEssential oilContent: 2-10 % (im äth. Öl)Leaf
Ester of menthol, imparting the fruity-sweet aroma component to the essential oil. Partly responsible for the organoleptic quality and hence the commercial grade classification of the oil (DAB/Ph. Eur.).
- Flavonoide (Luteolin, Apigenin, Eriocitrin, Hesperidin, Rutin)FlavonoidContent: 1-3 %Leaf
Diverse flavone glycosides and aglycones contributing to the choleretic (bile-stimulating), antioxidant and antispasmodic overall action of the leaf drug extract. Eriocitrin (a flavanone glycoside) and luteolin-7-glucoside are quantitatively prominent; hesperidin is capillary-protective.
- RosmarinsäurePhenolic acidContent: 0.5-2 %Leaf
Hydroxycinnamate ester (caffeic acid + 3,4-dihydroxyphenylalanine). Potently antioxidant, anti-inflammatory (COX-2 and LOX inhibition) and weakly antimicrobial. Together with other hydroxycinnamic acids forms the antioxidant fraction of the leaf; partly responsible for the shelf-life of dried drug.
- MenthofuranEssential oilContent: 1-9 % (im äth. Öl)Leaf
Monoterpenoid with furan ring — quality marker: high menthofuran content reduces essential oil quality (Ph. Eur. limit max. 8 %). Formed from (+)-pulegone by isomerisation; partly responsible for hepatotoxic potential at excessive doses of neat peppermint oil. Safe at therapeutic doses.
- Gerbstoffe (kondensierte und hydrolysierbare Tannine)TanninContent: 0.5-1.5 %Leaf
Small amounts of astringent tannins; contribute to mild mucous-membrane-protective action of leaf extract. Pharmacologically less significant than essential oil components — but play a role in the astringent effect of concentrated tea (e.g. traditional use in mild diarrhoea).
- Triterpene (Ursol-, Oleanolsäure — Spuren)OtherContent: SpurenLeaf
Pentacyclic triterpene acids in small amounts. Mildly anti-inflammatory and antimicrobial. Of secondary pharmacological significance in peppermint, but not entirely negligible in the overall synergy of the plant extract.
- [1]MonographEMA/HMPC/572705/2014 Rev.1 — European Union herbal monograph on Mentha × piperita L., folium (Peppermint Leaf), Final 15 Jan 2020(accessed: 2026-05-21)
- [2]MonographEMA/HMPC/522410/2013 Rev.1 — European Union herbal monograph on Mentha × piperita L., aetheroleum (Peppermint Oil), Final 15 Jan 2020(accessed: 2026-05-21)
- [3]MonographKommission E — Pfefferminzblätter (Menthae piperitae folium), Monographie positiv, BAnz Nr. 223, 1988; sowie Pfefferminzöl (Menthae piperitae aetheroleum), BAnz Nr. 223, 1988(accessed: 2026-05-21)
- [4]MonographESCOP Monographs — Menthae piperitae folium (Peppermint Leaf), 3rd edition 2016 (incl. supplement)(accessed: 2026-05-21)
- [5]MonographESCOP Monographs — Menthae piperitae aetheroleum (Peppermint Oil), 3rd edition 2016 (incl. supplement)(accessed: 2026-05-21)
- [6]MonographWHO Monographs on Selected Medicinal Plants — Volume 2: Folium Menthae Piperitae (Peppermint Leaf), WHO Geneva 2002(accessed: 2026-05-21)
- [7]MonographAlammar N et al. — The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. BMC Complement Altern Med. 2019;19(1):21. doi:10.1186/s12906-018-2409-0(accessed: 2026-05-21)
- [8]MonographGöbel H et al. — Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type. Der Nervenarzt 1996;67(8):672-681. PMID 8805113(accessed: 2026-05-21)
- [10]MonographPlants For A Future (PFAF) — Mentha × piperita database entry(accessed: 2026-05-21)
- [13]MonographASPCA Animal Poison Control — Mint (Mentha sp.): Toxic to Dogs, Toxic to Cats, Toxic to Horses(accessed: 2026-08-10)
- [9]BookWichtl M (Hrsg.) — Teedrogen und Phytopharmaka, 5. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart 2009: Menthae piperitae folium, S. 402-406(accessed: 2026-05-21)
- [11]WikipediaPfefferminze (Wikipedia DE)(accessed: 2026-05-21)
- [12]WikipediaPeppermint (Wikipedia EN)(accessed: 2026-05-21)
Distribution in Europe
🪴 Grow at home
- ☀ Light
- partial shade
- 💧 Water
- every few days
- 🌱 Soil
- Moist herb compost
- 🪴 Pot
- 20 cm
- ⭐ Difficulty
- ★☆☆ beginner
- 🐾 Pets
- toxic to pets
Tips:
- In its own pot — otherwise spreads.
- Partial shade better than full sun.
- Divide root in spring for new plants.
Care tips are general indoor-gardening recommendations, not scientific sources.
🤝 Permaculture Partners
In your garden, this plant acts as:
✨ Best symbiotic partners
- 🌿 Matricaria chamomilla Chamomile enhances mint aroma — Holzer favourite pair.
- 🌿 Urtica dioica Classic companion-planting partner.
⚠️ Better not planted together
- 🥬 Lavandula angustifolia Mint needs moist soil, lavender needs dry.
- 🥬 Spearmint Classic companion-planting partner.
- 🥬 Basil Mint overgrows basil and competes for water.
- 🥬 Parsley Classic companion-planting partner.
Source: Helga und Margarete Langerhorst, Mein gesunder Naturgarten (eigene Kuration)