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White Horehound
CautionAndorn · (Marrubium vulgare)
Mint family (Lamiaceae)
Description
White horehound is a woolly, perennial herb with grey-green, wrinkled leaves and small white lipped flowers gathered in dense false whorls around its square stem. It grows on dry waste ground and path edges and was named Germany's medicinal plant of the year in 2018. The flowering herb is harvested. Its pronounced bitterness comes from the diterpene lactone marrubiin, accompanied by phenylpropanoids such as acteoside and by flavonoids. The EMA lists horehound as a traditional remedy for cough associated with colds, while the German Commission E additionally assesses it positively for loss of appetite and digestive complaints — the bitter compounds stimulate saliva, gastric juice and bile flow. One thing to know: horehound is an active medicinal plant, not a harmless cup of herbal tea; at high doses marrubiin affects heart rhythm.
CONTRAINDICATED during pregnancy
Horehound is absolutely contraindicated in pregnancy. Marrubiin is uterotonic and was historically used as an abortifacient. Avoid even small amounts (tea, tincture). Only trace culinary doses in flavouring applications are historically unproblematic — therapeutic use strictly prohibited.
CONTRAINDICATED during breastfeeding
Horehound is contraindicated during lactation. Marrubiin and bitter phenylpropanoids pass into breast milk and may cause colic, digestive upset or diarrhoea in the infant. Avoid therapeutic doses. Culinary amounts (fresh leaves as flavouring) should also be avoided as a precaution during lactation.
CONTRAINDICATED for children
Per EMA monograph not suitable for children and adolescents under 18 — insufficient safety and efficacy data. Cardiac rhythm potential of marrubiin makes even low doses risky in children. Exception: culinary trace doses in horehound candy (traditional Anglo-Saxon) in household amounts.
Critical drug interactions with:
Antiarrhythmika (Amiodaron, Sotalol, Flecainid, Klasse-I- und III-Antiarrhythmika)
Traditional horehound herb tea as expectorant for cold-related and irritative cough, and as a bitter remedy for loss of appetite and dyspeptic complaints — main indication of the EMA monograph.
Preparation & dosage
INFUSION (EMA Traditional Use): 1.5–2.5 g dried, cut horehound herb (Herba Marrubii) in 200 ml boiling water, covered, steep 10 min, strain. Daily dose 4.5–7.5 g (3 single doses). Drink warm, moderately sweetened with honey. Indication (EMA traditional use): relief of cough in colds and irritative cough, mucus loosening (expectorant), and support for dyspeptic complaints and temporary loss of appetite. Mechanism: marrubiin (bitter lactone) reflexively stimulates bronchial secretion (secretomotoric) and promotes bile acid secretion (choleretic). Max 4 weeks without medical advice. Cough with fever, purulent sputum, dyspnoea or persistence beyond 1 week requires medical assessment.
- Dry amount
- 1.5–2.5 g
- Doses per day
- 3×
- Max duration
- 4 weeks
⚠ Age restriction: ≥ 18 years — Per EMA for adults and adolescents 18+ only — insufficient data for children under 18.
Alcoholic horehound tincture as alternative to tea — practical before meals as bitter tonic and expectorant for cold-related cough.
Preparation & dosage
TINCTURE (DER 1:5, ethanol 25–45 %): 1–2 ml (~20–40 drops) in water 3× daily, preferably before meals (for bitter-mediated action on bile and digestion). Daily dose equivalent to 4.5–7.5 g herb. Traditional use as for tea — expectorant and bitter tonic. Note ethanol content: unsuitable for alcohol dependence, severe liver disease, epilepsy. Not during pregnancy or lactation.
- Liquid amount
- 1–2 ml
- Doses per day
- 3×
- Max duration
- 4 weeks
⚠ Age restriction: ≥ 18 years — Adults 18+ only due to ethanol content and absence of paediatric data.
Bitter herb tea from horehound for stimulating digestion, bile production and bile flow — Kommission E positive assessment for loss of appetite and dyspepsia.
Preparation & dosage
BITTER TONIC TEA (Kommission E indication): 2–4 g dried horehound herb in 250 ml boiling water, covered, steep 10 min, strain. Drink unsweetened or minimally sweetened before meals — bitters are most effective when reaching taste receptors unimpeded. 3× daily before meals. Daily dose 6–12 g herb per Kommission E. Indication: loss of appetite, dyspeptic complaints, stimulation of bile and liver metabolism (cholagogue, choleretic). Marrubiin and its breakdown product marrubiinic acid measurably stimulate hepatic bile secretion.
- Dry amount
- 2–4 g
- Doses per day
- 3×
- Max duration
- 4 weeks
Folk use as bitter tonic and blood-purifying alterative for rheumatic complaints — no clinical evidence, documented historically only.
Preparation & dosage
HOREHOUND BITTERS TINCTURE (folk tradition): 1–1.5 ml (~20–30 drops) in water 2× daily. Folk medicine used horehound as a blood-purifying (alterative) remedy and for rheumatic complaints. No clinical evidence for these indications. Do NOT combine with cardiac medications (marrubiin has potential antiarrhythmic action at high doses). Adults only.
- Liquid amount
- 1–1.5 ml
- Doses per day
- 2×
- Max duration
- 6 weeks
Folk horehound gargle tea for sore throat, hoarseness and pharyngitis — astringent tannins soothe locally.
Preparation & dosage
GARGLE TEA: 2–3 g horehound herb in 200 ml boiling water, covered, steep 10 min, strain, cool to hand-warm. Gargle 30–60 sec 3–4× daily — do not swallow. Folk use for sore throat, hoarseness and pharyngitis. Astringent tannins and antimicrobial Lamiaceae tannins locally soothe the pharyngeal mucosa. Can be used alongside the herbal tea.
- Dry amount
- 2–3 g
- Doses per day
- 3×
- Max duration
- 2 weeks
Culinary use of young horehound leaves as intense bitter flavouring in digestifs, herbal liqueurs and traditional horehound candy (Anglo-Saxon folk cuisine).
Preparation & dosage
CULINARY & LIQUEUR: Young fresh horehound leaves in very small amounts as bitter-aromatic flavouring in herb vinegars, herb butter or savoury dishes. Horehound is an ingredient in traditional herbal liqueurs and digestifs (e.g. historic Marrubium bitters). For horehound candy (traditional Anglo-Saxon): boil fresh plant extract with sugar. Intensely bitter — use sparingly. Culinary doses (a few grams fresh herb daily) are considered safe.
Historical folk horehound tea for febrile colds as diaphoretic — in-vitro evidence for anti-inflammatory activity, clinical data lacking.
Preparation & dosage
FEVER TEA (historical folk use): 1.5–2 g horehound herb in 200 ml hot water, steep 8 min, strain, drink warm. 3× daily for febrile colds. Horehound was historically used as a diaphoretic and antipyretic. No clinical evidence for these effects; mild anti-inflammatory activity of phenylpropanoids and flavonoids documented in vitro. Fever above 39 °C, marked impairment or fever exceeding 3 days: seek medical care.
- Dry amount
- 1.5–2 g
- Doses per day
- 3×
- Max duration
- 2 weeks
IMPORTANT: Horehound (Marrubium vulgare) is a pharmacologically active medicinal plant — not a harmless herbal tea. Marrubiin has documented antiarrhythmic and potentially proarrhythmic properties at high doses (animal models). NEVER use with existing cardiac conditions, arrhythmias or cardiac medications without medical advice. Horehound is uterotonic — ABSOLUTELY CONTRAINDICATED in pregnancy (abortifacient in folk tradition). Avoid during lactation: bitter constituents pass into breast milk and may cause digestive upset in the infant. Not for children under 18 per EMA (insufficient safety data). Maximum use 4 weeks without medical advice. Persistent cough over 1 week, cough with fever, purulent sputum or dyspnoea require medical evaluation.
⏱ Max continuous use: 4 weeks
Horehound is absolutely contraindicated in pregnancy. Marrubiin is uterotonic and was historically used as an abortifacient. Avoid even small amounts (tea, tincture). Only trace culinary doses in flavouring applications are historically unproblematic — therapeutic use strictly prohibited.
Horehound is contraindicated during lactation. Marrubiin and bitter phenylpropanoids pass into breast milk and may cause colic, digestive upset or diarrhoea in the infant. Avoid therapeutic doses. Culinary amounts (fresh leaves as flavouring) should also be avoided as a precaution during lactation.
Per EMA monograph not suitable for children and adolescents under 18 — insufficient safety and efficacy data. Cardiac rhythm potential of marrubiin makes even low doses risky in children. Exception: culinary trace doses in horehound candy (traditional Anglo-Saxon) in household amounts.
Drug interactions
Antiarrhythmika (Amiodaron, Sotalol, Flecainid, Klasse-I- und III-Antiarrhythmika)
Marrubiin has documented antiarrhythmic properties (prolongation of action potential duration, sodium channel blockade in animal models). Additive or antagonistic interactions with antiarrhythmics are theoretically possible. At high doses: proarrhythmic potential (animal model). Combination to be strictly avoided or only under cardiological supervision with ECG.
Antidiabetika (Insulin, Sulfonylharnstoffe, Metformin, GLP-1-Agonisten)
In-vitro and animal studies show potential blood glucose-lowering properties of Marrubium extracts (inhibition of intestinal glucose absorption and possible insulin sensitisation). When combined with glucose-lowering medications, additive hypoglycaemia risk is possible. Monitor blood glucose more frequently.
Antihypertensiva (ACE-Hemmer, Betablocker, Calciumantagonisten, Diuretika)
Marrubium extracts show mild blood pressure-lowering activity in animal studies (vasodilatory via calcium channel blockade). Additive effect with antihypertensives possible — increased hypotension risk, especially in elderly patients. Monitor blood pressure regularly.
Gerinnungshemmer / Antikoagulantien (Warfarin, Phenprocoumon, NOAK)
Horehound contains flavonoids with potential antiplatelet activity (in vitro). Theoretically additive pro-bleeding effect when combined with anticoagulants or antiplatelet agents. Clinical relevance unproven, but caution advised in patients with unstable INR.
Contraindications
- Pregnancy — uterotonic and historically abortifacient action of marrubiin.
- Lactation — transfer of marrubiin and bitter constituents into breast milk with possible infant effects.
- Children and adolescents under 18 (therapeutic doses) — insufficient safety data per EMA.
- Known cardiac disease, arrhythmias or use of cardiac medications — marrubiin can have antiarrhythmic and, at high doses, proarrhythmic effects.
- Hypersensitivity to horehound or other Lamiaceae.
- Severe liver or biliary disease (biliary colic, bile duct obstruction) — choleretic action contraindicated in biliary obstruction.
Harvested part: flowering herb
- Time of day:
- On a dry, sunny morning (9–11 a.m.), once morning dew has fully evaporated. At this time essential oils and bitter compounds (marrubiin/premarrubiin) are at their peak — later harvest after the heat maximum is suboptimal.
- Drying:
- Cut the upper shoot tips with flowering whorls and young leaves (approx. the upper half of the plant — max. 20–30 cm) so the perennial regrows. Prefer flowering and pre-flowering shoots — marrubiin content is highest at full flowering. Bundle loosely and hang upside down in a shaded, well-ventilated spot at 25–35 °C. Alternatively spread in a single layer on drying racks. Drying time: 1–2 weeks, until leaves rustle and snap dry. Avoid overheating (above 40 °C) — marrubiin is relatively thermolabile. Strip fully dried herb (< 10 % residual moisture) from stems, coarsely chop, and store airtight in dark containers.
- Storage:
- 12 months — Airtight in dark glass or metal tins, cool and dry (max. 15–20 °C), protected from light. Use within 12 months — marrubiin content declines significantly after that. Discard if browning or loss of bitter scent occurs.
- Time of day:
- Morning (9–11 a.m.) after dew has dried. Harvest young leaves before full flowering — highest phenylpropanoid and mucilage content with still mild bitterness. Optimal for culinary use (flavouring, candy) or fresh plant tinctures.
- Drying:
- Spread healthy young leaves (without damaged or insect-eaten parts) singly or in loose layers on drying racks in shade at max. 35 °C. Good ventilation is critical — mould risk if layers are too thick. Drying time approx. 5–10 days. Dried leaves rustle and are parchment-brittle. For fresh plant tincture: immerse freshly harvested leaves in alcohol immediately (45–65 %, DER approx. 1:2 fresh, 1:5 dried).
- Storage:
- 8 months — Airtight, dark, dry and cool. Young leaves lose their aromatic profile faster than stems — use within 8 months.
- MarrubiinBitterContent: 0.3-1.0 %Aerial parts
Lead compound of horehound — a furanic diterpene bitter lactone (labdane type). Marrubiin itself is an artefact: in fresh plant the precursor premarrubiin is present, which cyclises spontaneously to marrubiin on drying and extraction. Primarily responsible for expectorant (secretomotoric reflex stimulation) and bitter tonic effect (bile acid and digestive secretion stimulation). In-vitro antiarrhythmic and calcium-antagonistic activity. Standardisation target for quality control per Ph.Eur. and EMA.
- PremarrubiinBitterContent: 0.5-1.5 %Aerial parts
Natural precursor of marrubiin in the fresh plant. Furanolactone of the labdane diterpene type. Converts spontaneously to marrubiin during drying by acid-catalysed cyclisation. Higher content in fresh herb than dried. Co-responsible for the intensely bitter taste of fresh herb.
- Phenylpropanoide (Acteoside / Verbascoside, Forsythoside B)Phenolic acidContent: 0.5-2.5 %Aerial parts
Phenylethanoid glycosides, widespread in the Lamiaceae family. Acteoside (= verbascoside) is the dominant fraction — antioxidant, anti-inflammatory (COX-1/COX-2 inhibition in vitro) and antimicrobial. Contribute to the immunological and antiviral properties attributed to horehound in folk medicine.
- Flavonoide (Luteolin-7-glucosid, Apigenin, Quercetin, Rutin)FlavonoidContent: 0.5-1.5 %Aerial parts
Flavones and flavonol glycosides with antioxidant, mildly spasmolytic and anti-inflammatory activity. Luteolin derivatives contribute to bronchial relaxation (in vitro: smooth muscle relaxation of bronchi). Complement the expectorant action of marrubiin.
- Ätherisches Öl (Limonen, beta-Pinen, Camphen, Sabinen, cis-Sabinhydrat)Essential oilContent: 0.05-0.3 %Aerial parts
Monoterpene-rich fraction of the essential oil with mildly antiseptic and expectorant properties. Low concentration explains the aromatic, slightly camphoraceous scent of the herb. Main components vary considerably by origin and harvest time. Partly responsible for the locally soothing action on the respiratory mucosa.
- Gerbstoffe / Lamiaceengerbstoffe (Rosmarinsäure, Chlorogensäure)TanninContent: 2.0-4.0 %Aerial parts
Rosmarinic acid is the quantitatively dominant phenylpropanoid alongside phenylethanoid glycosides. Strongly antioxidant, antimicrobial and anti-inflammatory. Astringent action on mucous membranes explains use as a gargle. Chlorogenic acid with mild choleretic activity complements marrubiin-mediated bile stimulation.
- Alkaloide (Betonicin, Stachydrin — Betaintyp)AlkaloidContent: 0.1-0.3 %Aerial parts
Quaternary ammonium alkaloids of the betaine type, characteristic of Lamiaceae. Betonicine (= L-betonicine) and the stereoisomer stachydrine. Pharmacologically of limited human relevance at these concentrations. Betonicine shows weak uterine-stimulating activity in animal studies, partially explaining the traditional pregnancy contraindication.
- Schleimstoffe / PolysaccharideMucilageContent: 5.0-8.0 %Aerial parts
Mucilages and acidic polysaccharides from uronic acids contribute to the mucosa-protective (demulcent) property of horehound tea. Soothe bronchial and pharyngeal mucosa — complement the mucolytic action of marrubiin with direct local protection. Explain why horehound tea as a cough tea feels less astringent than, e.g., pure thyme tea.
- [1]MonographEMA/HMPC/613545/2010 — European Union herbal monograph on Marrubium vulgare L., herba (Final, 2012)(accessed: 2026-05-21)
- [2]MonographKommission E — Marrubii herba (Andornkraut), Monographie (positiv), BAnz Nr. 43 vom 02.03.1989(accessed: 2026-05-21)
- [3]MonographESCOP Monographs — Marrubii herba (White Horehound Herb), 2nd edition 2003 with supplement(accessed: 2026-05-21)
- [4]MonographWHO Monographs on Selected Medicinal Plants — Volume 3: Herba Marrubii(accessed: 2026-05-21)
- [7]MonographPlants For A Future (PFAF) — Marrubium vulgare database entry(accessed: 2026-05-21)
- [5]BookWichtl, M. (Hrsg.) — Teedrogen und Phytopharmaka, 5. Auflage, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2009: Marrubii herba — Andornkraut(accessed: 2026-05-21)
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- [8]WikipediaGewöhnlicher Andorn (Wikipedia DE)(accessed: 2026-05-21)
- [9]WikipediaMarrubium vulgare — White Horehound (Wikipedia EN)(accessed: 2026-05-21)
Classical quotes
"Horehound is one of the oldest and most proven remedies for respiratory tract conditions."