© Photograph: Frank C. Müller, Baden-Baden · CC BY-SA 4.0 · Commons
Lettuce
Schnittsalat · (Lactuca sativa var. crispa)
Daisy family (Asteraceae)
Description
Unlike firm-headed lettuce, looseleaf lettuce never closes into a head; instead it forms open rosettes with curly or reddish-edged leaves that regrow continuously and can be picked leaf by leaf from May through October, another member of the daisy family. At roughly 125 µg/100 g it carries more vitamin K1 than butterhead types, plus ample beta-carotene, folate and – especially in red and curly cultivars – elevated quercetin along with kaempferol. In the kitchen and folk practice it is eaten raw for digestion, immunity and circulation, occasionally applied as a leaf compress for skin irritation, and a tea from the flowering herb is traditionally credited with calming properties. The milky sap of bolting plants contains lactucin and lactucopicrin, though normal leaf consumption stays safely low. Wash thoroughly before eating raw; those on vitamin K antagonists should keep intake steady.
Looseleaf or cutting lettuce is a cultivar group of Lactuca sativa that, unlike head lettuce, does not form a closed head but rather a loose rosette of curled or smooth, often coloured leaves (Lollo Rossa, Lollo Bionda, oakleaf). Eaten raw as a leaf salad it supplies per 100 g about 95 % water, around 14 kcal and meaningful amounts of vitamin K1, folate, provitamin A and potassium at very low energy density — a classic satiety vegetable that supports hydration and stimulates intestinal peristalsis through its dietary fibre.
Looseleaf lettuce is one of the richest vitamin K1 sources among lettuces: USDA data give approx. 125 µg phylloquinone per 100 g fresh — about 100 % of the daily requirement. Vitamin K is essential for carboxylation of coagulation factors II, VII, IX and X and for activating the bone protein osteocalcin. Dark green, red or bronze outer leaves contain substantially more vitamin K and carotenoids than the pale inner leaves and should be eaten rather than discarded.
Looseleaf lettuce is a relevant source of folate (vitamin B9, approx. 38 µg/100 g) and provitamin A in the form of beta-carotene (approx. 4400 µg/100 g, especially in dark green varieties). Folate is particularly important in early pregnancy for neural tube prevention; beta-carotene is converted to retinol as needed and supports vision, immune defence and skin integrity. Carotenoid absorption improves considerably when the salad is consumed with some fat (oil dressing).
In German and European folk medicine of the 18th and 19th centuries, a mild infusion of the bitter milky sap (lettuce opium, Latin lactucarium) from bolting lettuce plants was regarded as a gentle sleep aid, sedative and cough remedy. The dried white latex that exudes when the stem and leaf veins are cut was harvested; it contains the sesquiterpene lactones lactucin and lactucopicrin. Cutting lettuce (L. sativa) yields substantially milder concentrations than the related wild lettuce (L. virosa), from which pharmaceutical lactucarium was obtained. Clinical efficacy data in humans are lacking; the use is purely traditional folk medicine.
Preparation & dosage
In Central European household tradition, chilled washed lettuce leaves were placed as a cooling compress on tired, swollen eyelids, mildly irritated skin or minor redness. The high water content (~95 %) produces an evaporative cooling effect and eases subjective tension. The use is folkloric and not supported by clinical trials; not advisable on open wounds or eye infections.
Looseleaf lettuce is particularly well suited to the 'cut-and-come-again' method: instead of harvesting a whole head, only the outer leaves are cut or picked while the plant continues growing from its growing point. This allows continuous small harvests over several weeks — ideal for smoothies, mixed salads, as a wrap filling or garnish. Young leaves are particularly tender and mild; with age and approaching bolting they turn bitter.
LETTUCE OPIUM (lactucarium): The bitter milky sap of bolting lettuce contains the sesquiterpene lactones lactucin and lactucopicrin. In cultivated cutting/looseleaf lettuce, concentrations at customary salad amounts are safely low. Very large amounts of bolting plants or isolated milky sap may, according to PFAF, cause drowsiness, paradoxical over-excitation and in extreme doses cardiovascular effects — no practical risk at normal consumption. VITAMIN K: Looseleaf lettuce is among the vitamin K-richest lettuces (~125 µg/100 g); patients on vitamin K antagonists (warfarin, phenprocoumon) should keep their daily intake from leafy greens consistent rather than letting it fluctuate suddenly. CONTAMINATION RISK: Raw leafy salads may carry bacterial and viral pathogens (E. coli O157:H7, Salmonella, Listeria, norovirus) — wash thoroughly, use drinking-water-quality rinse water where possible and pay attention to provenance. ALLERGY: Rare Compositae/Asteraceae sensitisation is possible.
Looseleaf lettuce is very suitable in pregnancy — a valuable source of folate, vitamin A and vitamin K at minimal energy cost. Important: wash leaves thoroughly to minimise the risk of listeriosis or toxoplasmosis transmission via contaminated soil. Pre-washed bagged salads are often considered unproblematic in pregnancy but should still be additionally rinsed.
Safe during lactation. In very old traditions lettuce — including the milky sap — was considered galactagogue (milk-promoting); not scientifically substantiated. Pay attention to good hygiene and thorough washing.
Looseleaf lettuce is suitable from weaning age (approx. 8-10 months) — tender, finely chopped leaves as part of weaning foods. For toddlers, chop or puree finely; whole leaves only once reliable chewing is established to avoid choking. Hygiene: wash leaves thoroughly. Traditional lactucarium tea applications are not recommended for children.
Drug interactions
Vitamin-K-Antagonisten (Cumarin-Derivate wie Phenprocoumon/Marcumar, Warfarin)
Looseleaf lettuce contains approx. 125 µg vitamin K1 per 100 g and is among the vitamin K-richest lettuces. Strongly fluctuating daily salad amounts can destabilise the INR. Patients on coumarin therapy should keep total daily vitamin K intake from green vegetables consistent — not avoid it, but dose it evenly.
Sedativa und ZNS-dämpfende Arzneimittel (Benzodiazepine, Z-Substanzen, Opioide, Antihistaminika der 1. Generation)
With folk use of lettuce-opium infusions from bolting plants, an additive sedative effect with other CNS depressants is theoretically possible. At normal consumption of looseleaf lettuce as a food, this is not relevant; the caution refers to concentrated lactucarium preparations and mixtures with wild lettuce (L. virosa).
Contraindications
- Known hypersensitivity to Asteraceae (daisy family) — rare but possible. In Asteraceae allergy (e.g. mugwort, ragweed) cross-reactions with lettuce consumption are possible.
- Severe immunosuppression: raw leafy salads may carry Listeria, E. coli and other pathogens. Strongly immunosuppressed individuals should consume lettuce only well washed and after consulting their treating clinician.
- Severe renal failure with potassium restriction: include lettuce in the overall potassium balance — concentration per 100 g is low, but large consumption can contribute.
- Folk lactucarium tea applications are not a recognised replacement for sleep medication and should not be used long-term without professional advice; concentrated preparations are not recommended in pregnancy, lactation and childhood.
- Patients on coumarin anticoagulation: avoid sudden swings in daily lettuce amounts — INR stability through consistent intake.
Harvested part: individual leaves (cut-and-come-again)
- Time of day:
- Harvest in the morning or on cool evenings, when leaves are turgid with water — midday heat causes looseleaf lettuce to wilt. Cut-and-come-again: cut or pick outer leaves individually just above the growing point once fully grown but still tender (approx. 8-15 cm long). The plant continues growing from the centre; repeatable over several weeks. Flavour is mildest before bolting (elongation of the central axis).
- Drying:
- HARVEST AND STORAGE: Store harvested leaves unwashed in a perforated vegetable bag or container in the refrigerator vegetable drawer (0-2 °C, high humidity 95-98 %) — shelf life approx. 3-5 days. Wash in cold water and spin-dry well before use. Pressure-sensitive, do not stack. Do not store next to ethylene-producing fruits (apples, tomatoes). Looseleaf lettuce leaves are not suitable for drying — their high water content leads to wilting rather than preservation; for surplus, use smoothies or briefly braised 'wilted' lettuce greens.
- Storage:
- 0-2 °C, high humidity (95-98 %), unwashed, pressure-protected packaging. Separate from ethylene producers (apples, tomatoes).
- Time of day:
- Lactucarium harvest (folkloric, not for therapeutic use): in high summer, when individual plants are already bolting and forming flowering stems, cut the stems just above ground level in late morning on dry weather. The exuding milky sap is collected with a wooden or glass spatula and air-dried — it turns brown to almost black. Yield from L. sativa is low compared to the related L. virosa.
- Drying:
- Allow the exuded latex to air-dry until brittle, then store in airtight glass jars protected from light. Store dry, cool and dark — shelf life approx. 12 months. Note: pure lettuce opium is no longer pharmaceutically available; home preparation is purely traditional/folkloric.
- Storage:
- 12 months — Dry, cool (below 20 °C), dark, airtight in glass. Protect from moisture.
- Vitamin K1 (Phyllochinon)VitaminContent: ca. 125 µg/100 g frisch (Looseleaf)Leaf
Looseleaf lettuce is one of the richest vitamin K1 sources among lettuces — about 100 % of the daily requirement per 100 g. Dark green and red varieties (Lollo Rossa, oakleaf) supply considerably more phylloquinone than the paler inner leaves. Vitamin K1 is essential for blood coagulation and bone mineralisation.
- LactucinSesquiterpeneContent: Spuren in L. sativa; deutlich höher in L. virosaAerial parts
Bitter sesquiterpene lactone of the guaianolide group and one of the main constituents of lettuce opium (lactucarium). Present only in trace amounts in cultivated cutting lettuce; concentrations rise during bolting. Sedative and analgesic properties have been described in animal experiments; robust clinical evidence in humans is lacking.
- LactucopikrinSesquiterpeneContent: Spuren in L. sativa; höher in L. virosaAerial parts
Bitter principle (also called intybin) responsible for the intensely bitter taste of bolting lettuce. Lactucopicrin acts as an acetylcholinesterase inhibitor in animal studies and shows sedative and analgesic effects; antimalarial activity has been demonstrated in vitro. At dietary amounts from cultivated looseleaf lettuce, no pharmacologically relevant effect is expected.
- Beta-Carotin (Provitamin A)OtherContent: ca. 4400 µg/100 g (looseleaf, sortenabhängig)Leaf
Most important fat-soluble antioxidant in looseleaf lettuce; converted to retinol (vitamin A) as needed in the body. Dark green and red varieties contain many times more beta-carotene than iceberg lettuce. Absorption is markedly improved by added fat (oil dressing).
- Folsäure (Folat, Vitamin B9)VitaminContent: ca. 38 µg/100 g frischLeaf
Folate is essential for cell division and amino acid metabolism; particularly important in early pregnancy for neural tube prevention. Looseleaf lettuce is a moderate folate source — content is lower than butterhead types but considerably higher than iceberg.
- QuercetinFlavonoidContent: erhöht in roten und gekrausten SortenLeaf
Flavonol with antioxidant properties, considerably more concentrated in red and curled looseleaf varieties (Lollo Rossa, red oakleaf) than in pale ones. Quercetin contributes to the radical-scavenging capacity of leafy vegetables; pharmacologically relevant doses are not reached through diet.
- KämpferolFlavonoidContent: Spuren bis geringe MengenLeaf
Co-occurring flavonol alongside quercetin, also with antioxidant activity. Distribution mirrors quercetin, with higher levels in the colour-intense outer leaves of red and curled varieties.
- KaliumMineralContent: ca. 194-238 mg/100 g frischLeaf
Looseleaf lettuce is a moderate potassium source. Potassium is essential for neuromuscular function and blood pressure regulation. Owing to the high water content, potassium concentration per energy unit is high; under severe potassium restriction (advanced renal failure), lettuce consumption should be included in the balance.
- Wasser (Zellwasser mit gelösten Mineralstoffen)OtherContent: 94-96 %Leaf
The exceptionally high water content makes looseleaf lettuce a natural hydration vegetable with very low energy density (~14 kcal/100 g). The cell water contains osmotically active minerals (potassium, calcium, magnesium) and is a key factor behind the cooling and mildly diuretic effect known in folk medicine.
- [3]MonographUSDA FoodData Central — Lettuce, leaf, green, raw (SR Legacy)(accessed: 2026-05-27)
- [4]MonographLettuce, raw, green leaf — nutritional value per 100 g (nutritionvalue.org, citing USDA SR)(accessed: 2026-05-27)
- [5]MonographPlants For A Future (PFAF) — Lactuca sativa database entry(accessed: 2026-05-27)
- [1]WikipediaSchnittsalat (Wikipedia DE)(accessed: 2026-05-27)
- [2]WikipediaLettuce (Wikipedia EN)(accessed: 2026-05-27)
- [6]WikipediaLactucarium (Wikipedia EN)(accessed: 2026-05-27)
- [7]WikipediaLactucopicrin (Wikipedia EN)(accessed: 2026-05-27)
🤝 Permaculture Partners
In your garden, this plant acts as:
✨ Best symbiotic partners
- 🌿 Onion Classic companion-planting partner.
- 🌿 Cabbage Classic companion-planting partner.
- 🌿 Kohlrabi Classic companion-planting partner.
- 🌿 Carrot Classic companion-planting partner.
- 🌿 Fragaria vesca Classic companion-planting partner.
- 🌿 Radish Classic companion-planting partner.
📦 Part of these planting sets:
Source: Helga und Margarete Langerhorst, Mein gesunder Naturgarten (eigene Kuration)