© Franz Eugen Köhler, Köhler's Medizinal-Pflanzen · Public domain · Commons
Grapevine (red vine)
🐾Weinrebe (Rote Weinrebe) · (Vitis vinifera)
Grape family (Vitaceae)
Description
The grapevine is a woody climbing plant (liana) that reaches 10-20 metres using tendrils. Its large, palmately 3- to 5-lobed leaves have a heart-shaped base and turn a vivid red in autumn - this 'red vine leaf' (Vitis viniferae folium) is the medicinally used plant part. Flowers appear from June to August, and the fruit (grapes) ripen into dark blue-violet, green or yellowish berries. While the grapes serve as food, only the red autumn leaf is used for venous complaints.
CONTRAINDICATED for children
According to the EMA, grapevine leaf medicines should only be used in adults; use in children and adolescents is not recommended.
Standardised red vine leaf extract is used for chronic venous insufficiency - for swollen, heavy and tired legs, a feeling of tension, pain and night-time calf cramps. The EMA classifies this use as 'well-established use'; the flavonoids and tannins improve capillary sealing and reduce oedema.
Preparation & dosage
The grape is a popular food, supplying sugars, fruit acids and polyphenols; the skin contains resveratrol. Note: harmless for humans, but grapes and raisins are toxic to dogs (nephrotoxic).
Preparation & dosage
Red vine leaf extract is generally well tolerated; occasionally gastrointestinal upset (nausea, stomach ache), headache or hypersensitivity skin reactions (itching, reddening) occur. Sudden, one-sided leg swelling with pain, warmth or redness is NOT a case for self-treatment - see a doctor immediately (possible thrombosis). There is insufficient data on the extract in pregnancy and lactation. IMPORTANT: grapes and raisins (the fruit) are toxic to dogs and can cause acute kidney failure.
There is insufficient data on the use of red vine leaf extract during pregnancy; its use is therefore not recommended.
There is insufficient data on red vine leaf extract during lactation; its use is not recommended.
According to the EMA, grapevine leaf medicines should only be used in adults; use in children and adolescents is not recommended.
Drug interactions
Anticoagulants/antiplatelets
The polyphenols in vine leaf could theoretically affect blood clotting; monitor with a doctor when taken together with anticoagulant or antiplatelet medicines (e.g. warfarin, aspirin).
Contraindications
- Hypersensitivity (allergy) to grapevine leaf or any of the constituents.
Harvested part: Red vine leaf (leaves in autumn when coloured red)
- Quercetin-3-O-glucuronidFlavonoidLeaf
Marker compound of red vine leaf; vein-active flavonoid.
- Isoquercitrin (Quercetin-3-O-glucosid)FlavonoidLeaf
Further flavonoid glycoside in red vine leaf.
- AnthocyaneFlavonoidLeaf
Red pigments of the autumn leaf (e.g. cyanidin and malvidin glycosides), also in the grape skin.
- Oligomere Proanthocyanidine (kondensierte Gerbstoffe)TanninLeaf
Proanthocyanidin-type tannins, contributing to the capillary-sealing effect.
- PhenolcarbonsäurenOtherLeaf
Phenolic acids (e.g. caffeic acid derivatives) in the leaf.
- Resveratrol (Stilben)OtherFruit
Stilbene phytoalexin, mainly in the grape skin.
- [1]MonographEMA - European Union herbal monograph on Vitis vinifera L., folium (grapevine leaf / red vine leaf)(accessed: 2026-07-02)
- [6]MonographESCOP Monographs - Vitis viniferae folium (Red Vine Leaf)(accessed: 2026-07-02)
- [2]WikipediaWeinrebe - Wikipedia (Deutsch)(accessed: 2026-07-02)
- [3]WikipediaVitis vinifera - Wikipedia (English)(accessed: 2026-07-02)
- [5]WikipediaGrape and raisin toxicity in dogs - Wikipedia(accessed: 2026-07-02)
- [7]CommonsVitis vinifera - Köhler's Medizinal-Pflanzen (Plate 145) - Wikimedia Commons(accessed: 2026-07-02)
- [4]WikidataVitis vinifera (Q22715) - Wikidata(accessed: 2026-07-02)
🤝 Permaculture Partners
In your garden, this plant acts as: