© Drew Avery · CC BY 2.0 · Commons
Hippeastrum
Toxic🐾Ritterstern · (Hippeastrum vittatum)
Amaryllis family (Amaryllidaceae)
Description
The amaryllis of the winter windowsill grows from a thick bulb lifted and dried in summer: between December and February it sends up a stout hollow stalk topped by two to six large, star-spread blooms, usually red with white stripes. Since the late 19th century, Dutch and Brazilian growers have raised the bulbs over two to three years and shipped them to Europe each autumn. Its German name, Ritterstern, refers to the star-shaped flower and is probably a rendering of the Latin Hippeastrum, roughly knight's star. The plant has no medicinal use. Every part, above all the bulb, contains Amaryllidaceae alkaloids — chiefly lycorine — along with needle-shaped calcium oxalate crystals. Skin inflammation has been documented among florists and bulb sorters, while swallowed pieces of bulb cause nausea and vomiting. In homes with children or pets it therefore belongs well out of reach.
🌿 Risk of confusion — read before wild-harvesting!
The classic poisoning occurs — analogous to narcissus — through accidental confusion of the dried bulb with kitchen onion or shallot, particularly after Christmas gifts, when the spent bulbs find their way into kitchens and pantries.
External use only!
This plant must NOT be taken internally. Use only as compress, salve, or bath.
CONTRAINDICATED during pregnancy
Lycorine and other Amaryllidaceae alkaloids inhibit ribosomal protein biosynthesis and are embryotoxic in vitro as well as teratogenic in animal studies. Any oral or high-dose topical application of Hippeastrum material during pregnancy is contraindicated. Skin contact with the plant sap should also be consistently avoided in pregnancy by wearing gloves, since systemic absorption through sensitised or damaged skin cannot be ruled out.
CONTRAINDICATED during breastfeeding
Transfer of Amaryllidaceae alkaloids into breast milk is insufficiently studied; given the acute toxicity (vomiting, seizures) for the infant, any internal use is strictly contraindicated. For purely indoor and gift-plant use, breastfeeding mothers are not at risk provided skin contact with the plant sap is consistently avoided.
CONTRAINDICATED for children
Children classically poison themselves by biting into the large, attractive bulb — as a Christmas gift plant, Hippeastrum vittatum is particularly risky in households with small children. Even a piece of bulb scale can trigger severe vomiting and dehydration. The plant should be placed out of reach of climbing children; after flowering, store the bulb in a sealed container (clearly labelled as 'amaryllis — toxic'). On accidental ingestion: poison control hotline, no self-induced vomiting, present to medical care as quickly as possible. No lay use in children.
Critical drug interactions with:
Cholinesterase-Hemmer (Donepezil, Rivastigmin, Galantamin, Pyridostigmin)
The striped Barbados lily (Hippeastrum vittatum) is the classic 'winter amaryllis' of the Central European living room — as a Christmas and Advent gift plant, the forced bulb has been established in Dutch and German floristry since the late 19th century. Between December and February, a large dried bulb sends up a leafless flowering scape within four to six weeks bearing two to six funnel-shaped, red-and-white striped blooms of 12 to 18 centimetres diameter. Important clarification: in everyday language the plant is almost always called 'amaryllis', but botanically it belongs to the genus Hippeastrum (around 80 South American species, indoor forcing culture). The true botanical genus Amaryllis comprises only a single species, Amaryllis belladonna from the South African Cape, which blooms outdoors in late summer. Both genera were frequently confused in the 19th century; the taxonomic separation was definitively settled in 1987 by the International Association for Plant Taxonomy.
Industrial cut-flower production: Dutch and Brazilian specialist nurseries grow Hippeastrum bulbs over two to three years in open field or tunnel culture, harvest and dry them in summer and ship dried bulbs (calibre 26 to 36 centimetres circumference) to European retail in autumn. In parallel, cut flowering stems with buds are traded during the pre-Christmas and wedding season; with a vase life of two to three weeks they are among the longest-lasting cut flowers. Key production hubs sit in the Netherlands (Hillegom, Lisse) and in the Brazilian states of São Paulo and Rio Grande do Sul. Because of considerable collector value, rare wild Hippeastrum species are threatened in Brazil and regulated under CITES Appendix II (protection applies to wild-collected material, not to the cultivated gift plant H. vittatum).
Naming and symbolism: the German common name 'Ritterstern' (knight's star) refers to the star-shaped spread of the bloom and the chivalric red tepals streaked with white — presumably a translation of the Latin genus name Hippeastrum ('horseman's star', from Greek hippeus = horseman and astron = star), introduced by the English plant enthusiast William Herbert in 1837. The common name 'amaryllis' goes back to the eponymous shepherdess Amaryllis from Virgil's Eclogues (pastoral poems, 1st century BCE) and was originally assigned by Linnaeus in 1753 to the whole group, later restricted to the South African Amaryllis belladonna. The purely cultural and linguistic-historical significance — use as a gift and Christmas symbol, wedding flower, symbol of steadfastness in Victorian flower language — far outweighs any medicinal connection.
South American ethnobotany: indigenous Andean peoples (Quechua, Aymara) as well as tribes in the Brazilian Amazon highlands historically used various Hippeastrum relatives as components of plant-based arrow and spear poisons. The bulbs were crushed, fermented and applied to arrow tips — the contained Amaryllidaceae alkaloids (especially lycorine) act as central nervous system depressants and supported hunting success for small game. There is NO documented indigenous medicinal use of Hippeastrum bulbs — the ethnobotanical connection is purely toxicological-technical for hunting purposes. This entry is purely documentary; due to the acute toxicity (see safety notes) and the danger to modern users, any imitation is expressly warned against. The cultural significance has largely been lost with the disappearance of traditional hunting practices.
Toxicity warning note — not a remedy: the fresh plant sap contains Amaryllidaceae alkaloids and calcium oxalate raphides which, on repeated skin contact (typically in florists, gardeners and bulb sorters in the Netherlands), trigger an irritant to allergic contact dermatitis — the so-called 'amaryllis dermatitis' or 'Hippeastrum hand'. Symptoms: redness, itching, small vesicles on hands and forearms within hours to days of exposure; sensitised individuals may show acute urticarial reactions. Prevention: nitrile or leather gloves when repotting, cutting and removing spent flower scapes. This is explicitly an ethnobotanical or occupational medicine warning, not a therapeutic indication.
⚠ External use only
TOXIC — ALL PLANT PARTS, ESPECIALLY THE BULB. Hippeastrum vittatum contains the typical Amaryllidaceae alkaloids (lycorine as the main component, plus hippeastrine, vittatine, tazettine, traces of pancratistatin and galantamine) along with calcium oxalate raphides. The classic poisoning occurs — analogous to narcissus — through accidental confusion of the dried bulb with kitchen onion or shallot, particularly after Christmas gifts, when the spent bulbs find their way into kitchens and pantries. Symptoms (oral): within 15 to 90 minutes nausea, severe vomiting, diarrhoea, cramping abdominal pain, salivation, sweating, dizziness, circulatory disturbances; with larger amounts tremor, seizures, tachycardia, in severe cases respiratory paralysis. Dermal: florist's eczema, contact dermatitis from repeated sap exposure. Pets — particularly cats — are highly sensitive; a single chewed bulb scale can trigger vomiting, tremor and epileptiform seizures in cats (frequent emergency presentations to veterinarians between December and February). On suspected oral poisoning: poison control hotline (Germany: regional poison information centres, Austria: VIZ, Switzerland: Tox Info Suisse), abundant water, NO salt water for induced vomiting. Present children and pets to medical or veterinary care without delay. ASPCA classification (accessed 2026-08-10): toxic to dogs and cats. The ASPCA classifies the whole genus this way.
Lycorine and other Amaryllidaceae alkaloids inhibit ribosomal protein biosynthesis and are embryotoxic in vitro as well as teratogenic in animal studies. Any oral or high-dose topical application of Hippeastrum material during pregnancy is contraindicated. Skin contact with the plant sap should also be consistently avoided in pregnancy by wearing gloves, since systemic absorption through sensitised or damaged skin cannot be ruled out.
Transfer of Amaryllidaceae alkaloids into breast milk is insufficiently studied; given the acute toxicity (vomiting, seizures) for the infant, any internal use is strictly contraindicated. For purely indoor and gift-plant use, breastfeeding mothers are not at risk provided skin contact with the plant sap is consistently avoided.
Children classically poison themselves by biting into the large, attractive bulb — as a Christmas gift plant, Hippeastrum vittatum is particularly risky in households with small children. Even a piece of bulb scale can trigger severe vomiting and dehydration. The plant should be placed out of reach of climbing children; after flowering, store the bulb in a sealed container (clearly labelled as 'amaryllis — toxic'). On accidental ingestion: poison control hotline, no self-induced vomiting, present to medical care as quickly as possible. No lay use in children.
Drug interactions
Cholinesterase-Hemmer (Donepezil, Rivastigmin, Galantamin, Pyridostigmin)
Hippeastrum bulbs contain small amounts of galantamine plus other Amaryllidaceae alkaloids with cholinergic activity. Accidental ingestion of plant material in addition to therapeutically taken cholinesterase inhibitors can trigger additive cholinergic effects (bradycardia, bronchospasm, seizures, cholinergic crisis) — clinically relevant only in plant material poisoning, but theoretically mandatory to consider.
Anticholinergika (Atropin, Scopolamin, Trizyklische Antidepressiva, Antihistaminika erster Generation)
Anticholinergics antagonise the cholinergic transmission enhanced by lycorine and galantamine — in acute poisoning with Hippeastrum material, atropine is deliberately used in emergency medicine as antidote (analogous to therapy of cholinesterase inhibitor poisoning). With pre-existing chronic anticholinergic medication the typical poisoning symptomatology may be blunted and thereby masked.
Zytostatika und Proteinbiosynthese-Hemmer
Lycorine and narciclasine inhibit ribosomal protein biosynthesis; with simultaneous intake of Hippeastrum material and oncological cytostatic agents (especially topoisomerase and protein biosynthesis inhibitors) additive bone marrow and gastrointestinal toxicity is theoretically conceivable. Practically relevant only in accidental poisoning; not therapeutically usable.
Contraindications
- Any form of oral self-administration of Hippeastrum material — no safe home dose possible, no established medicinal use; the EMA HMPC does not list Hippeastrum.
- Known Amaryllidaceae allergy (narcissus, snowdrop, Hippeastrum) — cross-sensitisation is clinically documented; consistently avoid all skin contact with the sap.
- Pregnancy, breastfeeding, children and adolescents under 18 years — see notes above; lycorine is embryotoxic and acutely systemically toxic.
- Households with cats, dogs, birds or small rodents — Hippeastrum bulbs are markedly toxic to pets (vomiting, tremor, seizures, cardiac arrhythmias); keep the plant out of reach or avoid altogether.
- Individuals with existing gastrointestinal ulcers, reflux disease or chronic renal impairment should particularly strictly avoid the plant sap; on skin contact rinse promptly with lukewarm water and mild soap.
Harvested part: bulb
- Time of day:
- Cut-flower harvest during the pre-Christmas and wedding season (December to February) in heated Dutch glasshouses; cutting takes place in the early morning hours as soon as the first bud begins to open and the remaining buds show clear colouration. Cut point about five centimetres above the bulb. PROTECTIVE GLOVES MANDATORY — lycorine and calcium oxalate raphides in the cut sap reliably trigger so-called 'Hippeastrum hand' or 'amaryllis dermatitis'.
- Drying:
- Cut flowers are not dried but shipped fresh in water. Vase life two to three weeks at room temperature with daily water changes; stabilise hollow stems with support sticks or cotton plugs if needed. Do NOT combine cut sap with other cut flowers in the same vase — the Amaryllidaceae alkaloids are phytotoxic.
- Storage:
- Transport fresh flowers cool (8 to 12 degrees Celsius) and in the dark; at normal room temperature the blooms last two to three weeks in the living room. Place out of reach of children and pets.
- Time of day:
- Bulb harvest in specialist nurseries (Netherlands, Brazil) in high summer and early autumn (July to September) after the foliage has fully died down. The bulbs are carefully lifted from the soil, freed from roots and old scale tissue, and graded by calibre (26 to 36 centimetres circumference). PROTECTIVE GLOVES MANDATORY — direct skin contact with the bulb sap reliably triggers contact dermatitis, particularly in repeated occupational exposure. NO medicinal harvest — the bulb is intended exclusively for gift plant and cut flower culture.
- Drying:
- Bulbs are kept at 17 to 25 degrees Celsius under controlled humidity (50 to 70 percent) in slow dormancy for four to twelve weeks, then packed in individual mesh bags for autumn shipping. Replanting in clean potting soil activates the forcing phase. Store separately from kitchen onions, garlic and food — confusion risk with clinically documented poisonings!
- Storage:
- Dry, cool (8 to 17 degrees Celsius), dark, well ventilated, out of reach of children and pets; label containers clearly as 'amaryllis bulb — toxic'; NEVER store in kitchen cabinets or among kitchen onions.
- LycorineAlkaloidContent: 0.1-0.4 % in der Zwiebel (variabel nach Sorte und Erntezeit)use.plant_part.bulb
Lead alkaloid of the entire Amaryllidaceae family and main contributor to the acute toxicity of Hippeastrum vittatum. Pyrrolophenanthridine skeleton; inhibits ribosomal protein biosynthesis (peptidyl transferase activity) and thereby triggers severe vomiting, cramping abdominal pain, tremor and seizures. LD50 oral mouse approximately 41 mg/kg. Lycorine is also the central forensic marker for identification of Hippeastrum or narcissus poisoning in clinical toxicology.
- HippeastrineAlkaloidContent: Spuren bis 0.1 % in der Zwiebeluse.plant_part.bulb
Characteristic accompanying alkaloid of the genus Hippeastrum (eponymous); structurally related to lycorine (pyrrolophenanthridine type). Hippeastrine contributes secondarily to the emetic effect and to central nervous system actions. Used in pharmacological research as a chemotaxonomic marker distinguishing Hippeastrum from Amaryllis, Narcissus and Galanthus.
- VittatineAlkaloidContent: Spuren bis 0.05 % in der Zwiebeluse.plant_part.bulb
Special alkaloid of the crinine type named after Hippeastrum vittatum; detectable in small amounts in the bulb. Structurally it is the enantiomer of crinine (from Crinum). Vittatine shows moderate cytotoxic and antiviral activity in vitro but has no practical therapeutic application — relevance primarily as a chemotaxonomic marker and in natural product chemistry.
- TazettineAlkaloidContent: Spuren in der Zwiebel und im Blattuse.plant_part.bulb
Haemanthamine-type alkaloid that also occurs in Narcissus tazetta and other Amaryllidaceae. Present in Hippeastrum vittatum in low concentration. Tazettine shows weak hypotensive and antitumour effects in vitro; in acute toxicology its relevance is minor compared to lycorine. Discussed in phytochemical research as a marker for stem relationship of the tribes Narcisseae and Hippeastreae.
- PancratistatinAlkaloidContent: Spuren in der Zwiebeluse.plant_part.bulb
Isocarbostyril alkaloid with marked antiproliferative activity in vitro (apoptosis induction in various tumour cell lines); originally isolated from Pancratium littorale, also detectable in traces in Hippeastrum species. Pancratistatin is the subject of preclinical cancer research but has NO clinical approval and no therapeutic application in humans. Because of the low concentration in H. vittatum, it barely contributes to acute toxicity.
- GalantamineAlkaloidContent: Spuren (deutlich geringer als in Galanthus oder Narcissus 'Carlton')use.plant_part.bulb
Selective competitive acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors; pharmaceutically standardised (Reminyl®, Razadyne®) approved for mild to moderate Alzheimer's dementia. Hippeastrum is NOT a relevant commercial source — global galantamine supply comes predominantly from Narcissus 'Carlton', Galanthus woronowii and increasingly from total synthesis. In Hippeastrum vittatum only in traces; nevertheless contributes to the cholinergic component of the poisoning symptomatology.
- Calciumoxalat-RaphidenOtherContent: deutlich nachweisbar in Zwiebel und Saftuse.plant_part.bulb
Needle-shaped calcium oxalate crystals in specialised idioblasts of the bulb scales and leaf tissue; mechanically irritant to skin and mucous membranes. Main contributor to the mechanical component of 'amaryllis dermatitis' (florist's eczema) and to acute oral mucosal irritation in accidental ingestion. Act synergistically with the Amaryllidaceae alkaloids.
- Carotinoide und AnthocyaneFlavonoidContent: nicht quantifiziert (Blüten)Flower
The typical red-and-white striped pattern of the flowers is produced by anthocyanins (cyanidin and pelargonidin glycosides) in the red zones and by the absence of pigment deposition in the white stripes; traces of carotenoids additionally contribute to the overall colouration. These compounds have no relevance for the toxicological and pharmacological evaluation of the plant — only ornamental appeal of the gift plant.
- [3]MonographHippeastrum vittatum (L'Hér.) Herb. — Plants of the World Online (Kew)(accessed: 2026-05-27)
- [4]MonographHippeastrum vittatum — Royal Horticultural Society Plant Finder(accessed: 2026-05-27)
- [5]MonographAmaryllis (Hippeastrum spp.) — ASPCA Toxic and Non-Toxic Plants Database(accessed: 2026-05-27)
- [6]MonographAmaryllidaceae alkaloids: chemistry and toxicology of Hippeastrum and related genera — review(accessed: 2026-05-27)
- [8]MonographASPCA Animal Poison Control — Barbados Lily (Hippeastrum spp.)(accessed: 2026-08-10)
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- [1]WikipediaHippeastrum vittatum (Wikipedia EN)(accessed: 2026-05-27)
- [2]WikipediaRitterstern (Hippeastrum) — Wikipedia (DE)(accessed: 2026-05-27)
- [7]WikidataHippeastrum vittatum (Wikidata Q161244)(accessed: 2026-05-27)