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Cyclamen persicum
Toxic🐾Zimmer-Alpenveilchen · (Cyclamen persicum)
Primrose family (Primulaceae)
Description
With its swept-back, butterfly-like flowers and marbled, heart-shaped leaves, the Persian cyclamen is one of the most popular winter-flowering houseplants, typically blooming from October to March. A member of the primrose family, it forms an underground tuber containing saponin glycosides such as cyclamin. A standardised tuber extract has been studied clinically in relation to respiratory complaints, and folk medicine also made external use of the plant for skin problems. For home use, though, the whole plant is best regarded purely as ornamental: the tuber is toxic and must never be taken internally, as even small amounts can cause vomiting, diarrhoea and abdominal pain. It is highly toxic to dogs, cats and birds, and the sap may irritate skin and eyes.
External use only!
This plant must NOT be taken internally. Use only as compress, salve, or bath.
CONTRAINDICATED during pregnancy
Cyclamin and related saponins may exert uterine-contracting effects. Internal use during pregnancy is strictly contraindicated; external application also to be avoided.
CONTRAINDICATED during breastfeeding
No safety data available. Due to saponin toxicity, no use during lactation.
CONTRAINDICATED for children
Tuber is highly toxic — young children are at particular risk. Keep plant out of reach of children. No application in children under 18 years.
Cyclamen persicum is cultivated as a winter-flowering potted plant indoors. Its blooming season from October to March fills the decorative gap in many living spaces. Preferring cool temperatures and indirect light (12–16 °C, no direct sun), it is particularly suited to cool stairwells, hallways, and bedrooms.
Historically in folk medicine, crushed or macerated cyclamen tubers were used externally as a counter-irritant rubefacient for gout, rheumatic joints, and skin rashes. The saponins (cyclamin, hederagenin glycosides) are believed to exert a locally irritant-rubefacient action. This application is documented solely historically and, due to saponin toxicity, is only defensible externally — strict avoidance of mucous membrane and eye contact.
In several European folk medicine traditions, freshly grated cyclamen tubers were applied as compresses to furuncles, stubborn abscesses, and wounds to accelerate maturation. The saponin-rich plant juice is described as antiseptic and mildly skin-irritating. Hildegard of Bingen describes related Cyclamen species (Cyclamen europaeum) in her phytomedicinal writings for similar applications.
Saponin-containing extracts from Cyclamen europaeum (closely related to C. persicum) are used in nasal sprays (e.g. CYCLAMED) for acute rhinosinusitis. The hypertonic saponin solution induces secretolysis and mucosal drainage of the paranasal sinuses without systemic absorption. Cochrane Review 2014 (Zalmanovici Trestioreanu & Barua) rates clinical evidence as limited but methodologically permissible. This application applies only to certified finished preparations — NOT to self-made extracts.
Preparation & dosage
Samuel Hahnemann included Cyclamen europaeum in his homeopathic pharmacopoeia (Materia Medica Pura). In a homeopathic context, highly diluted cyclamen preparations (D6–D30) are applied for dizziness, nausea, and menstrual complaints. The folk classification reflects the finding that at homeopathic high dilutions no pharmacologically active constituent remains detectable.
Traditionally, cyclamen tubers were soaked in water in some Mediterranean regions to produce a mild rinse for skin parasites (scabies, lice). The saponins act as membrane-destabilising agents on small organisms. This practice is historically documented but dangerous: overdosing or swallowing causes severe irritation of the gastrointestinal mucosa.
⚠ External use only
TOXIC — especially the tuber. Cyclamen persicum contains saponin glycosides (cyclamin, hederagenin glycosides) that can cause vomiting, diarrhoea, severe abdominal pain, and at high doses cardiac arrhythmias upon ingestion. The tuber is HIGHLY TOXIC to dogs, cats, and birds (saponin-induced haemolysis and mucosal irritation). Contact with tuber juice: skin and eye irritation possible. NEVER use the plant internally. All application forms exclusively external and only historically documented — no modern therapeutic recommendation. ASPCA classification (accessed 2026-08-10): toxic to dogs and cats. The ASPCA classifies the whole genus this way.
Cyclamin and related saponins may exert uterine-contracting effects. Internal use during pregnancy is strictly contraindicated; external application also to be avoided.
No safety data available. Due to saponin toxicity, no use during lactation.
Tuber is highly toxic — young children are at particular risk. Keep plant out of reach of children. No application in children under 18 years.
Drug interactions
Herzglykoside (Digitalis, Digoxin)
Cyclamin can exert cardiac effects at overdose; additive effect on cardiac rhythm with glycosides theoretically possible. Relevance minimal with purely external application; note with mucosal exposure.
Contraindications
- Any internal use (tubers, leaves, juice) — contraindicated without exception
- Pregnancy and lactation
- Children and adolescents under 18 years
- Known hypersensitivity to Primulaceae (cross-reaction with Primula saponins possible)
- Contact with eyes and mucous membranes (saponin-induced irritation)
Harvested part: tuber
- Time of day:
- Morning in dry weather, when the plant is in summer dormancy (foliage dried back).
- Drying:
- Tubers only for scientific/historical documentation — NOT for therapeutic preparation. Fresh tuber: photograph immediately after harvest and store per specialist literature.
- Storage:
- 6 months — Store dried tubers dry, dark, and completely inaccessible to children and pets. Label all containers as TOXIC.
- Time of day:
- Morning for decorative cut flower use; flowers open with daylight.
- Drying:
- Flowers are difficult to dry (high water content). Use fresh for decoration or silica-gel drying at max. 25 °C.
- Storage:
- 2 months
- CyclaminSaponinContent: 0.3-1.5 %use.plant_part.bulb
Lead saponin of Cyclamen species; a triterpenoid glycoside with hederagenin aglycone. Haemolytically active, causes severe mucosal irritation upon ingestion. Historically described as a laxative and emetic — too dangerous for internal use.
- Hederagenin-GlykosideSaponinuse.plant_part.bulb
Saponins structurally related to cyclamin; characterised in Cyclamen hederifolium and C. graecum (Harvala 1978, Altunkeyik 2012). Contribute to the overall toxicity of the tubers.
- IsocyclaminSaponinuse.plant_part.bulb
Structural isomer of cyclamin; configuration of cyclamiretin C and structure of isocyclamin characterised by Reznicek et al. (1989).
- Cyclamic acid (Cyclamiretin A)Saponinuse.plant_part.bulb
Triterpene sapogenin acting as aglycone of several cyclamen saponins; antibacterial and antifungal in vitro.
- Flavonoide (Rutin, Quercetin-Glykoside)FlavonoidLeaf
Flavonoid glycosides detected in the leaves; antioxidant properties, no contribution to toxicity.
- Stärke (Amylose/Amylopektin)PolysaccharideContent: ca. 30-50 % TGuse.plant_part.bulb
Main energy reserve of the tuber; no medicinal value, but explains the high weight of the tubers.
- Phenolsäuren (Kaffeesäure-Derivate)Phenolic acidAerial parts
Found in aerial plant parts (leaves, stems); low concentration, antioxidant character.
- [1]MonographHarvala C. et al. (1978): Saponins from Cyclamen hederifolium and C. graecum. Planta Medica 34(3):294–302(accessed: 2026-05-24)
- [2]MonographReznicek G. et al. (1989): Saponins in Cyclamen species: Configuration of cyclamiretin C and structure of isocyclamin. Phytochemistry 28(3):825–828(accessed: 2026-05-24)
- [3]MonographZalmanovici Trestioreanu A., Barua A. (2014): Cyclamen europaeum extract for acute sinusitis. Cochrane Database Syst Rev 2014(accessed: 2026-05-24)
- [4]MonographLeupen M. (2010): Cyclamen europaeum. Homoeopathic Links 23(1):45–50(accessed: 2026-05-24)
- [7]MonographASPCA Animal Poison Control — Cyclamen (Cyclamen spp)(accessed: 2026-08-10)
- [8]MonographCliniTox Giftpflanzen — Cyclamen persicum Mill.: giftig + (Institut für Veterinärpharmakologie und -toxikologie, Universität Zürich)(accessed: 2026-08-10)
- [5]WikipediaWikipedia DE: Persisches Alpenveilchen (Cyclamen persicum)(accessed: 2026-05-24)
- [6]WikipediaWikipedia EN: Cyclamen persicum(accessed: 2026-05-24)