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Buxus sempervirens
Toxic🐾Gewöhnlicher Buchsbaum · (Buxus sempervirens)
Box family (Buxaceae)
Description
Dense evergreen foliage and an exceptional tolerance for clipping have made box the backbone of formal garden design since antiquity — from Versailles to monastery gardens, it is shaped into hedges, spheres and topiary figures. Its extremely dense wood, heavy enough to sink in water, was traditionally used for wood-engraving blocks, recorders and chess pieces. Every part of the plant, however, is toxic: more than 100 steroid alkaloids, including cyclobuxine D and buxine, can trigger severe poisoning — vomiting, bloody diarrhoea, respiratory paralysis — even in small amounts. Historically, leaf decoctions were mistakenly used as a 'plant quinine' against malaria, a practice now regarded as obsolete and dangerous. External use against hair loss likewise lacks scientific support. In case of suspected poisoning, contact poison control immediately; internal self-use of any kind, including tea or tincture, is strongly discouraged.
External use only!
This plant must NOT be taken internally. Use only as compress, salve, or bath.
CONTRAINDICATED during pregnancy
Strictly contraindicated. Boxwood steroid alkaloids cross the placenta; abortifacient and teratogenic effects are documented from veterinary poisoning cases in pregnant animals. External use of extensive tinctures should also be avoided.
CONTRAINDICATED during breastfeeding
Contraindicated. Lipophilic steroid alkaloids pass into breast milk; infants are particularly at risk due to immature hepatic metabolism. No internal use during breastfeeding.
CONTRAINDICATED for children
Contraindicated. Children are particularly at risk due to low body weight and tendency to put attractive leaves and capsules in their mouth. A few leaves alone can cause severe symptoms in toddlers. Box plants in front gardens and playgrounds are problematic.
Critical drug interactions with:
Zentral dämpfende Substanzen (Benzodiazepine, Opioide, Alkohol) · Hepatotoxische Medikamente (Paracetamol-Hochdosis, Methotrexat, Isoniazid)
Classical garden and cemetery hedging plant; due to extremely dense growth and excellent response to clipping, Buxus has been the leading species of formal gardening since antiquity (topiary, knot gardens, parterres). Famous installations at Versailles, Villa d'Este and Sissinghurst use boxwood as architectural backbone. Since 2007 severely threatened in Central Europe by the invasive box tree moth (Cydalima perspectalis) and box blight (Cylindrocladium buxicola).
Wood use — boxwood, with a raw density of 0.95-1.03 g/cm³, ranks among the densest European woods and sinks in water. Traditional applications include wood-engraving blocks (Thomas Bewick, 18th century), woodwind instruments (recorders, clarinet mouthpieces, bagpipe chanters), weaving shuttles, chess pieces, tool handles, carving and turnery work. Today one of the most heavily traded European fine timbers.
HISTORICALLY OBSOLETE — In folk-medicine tradition, alcoholic boxwood extracts were rubbed externally against hair loss (alopecia) and marketed as a hair tonic. Efficacy is not established; percutaneous absorption of alkaloids cannot be excluded. Today without indication, documented only as ethnobotanical record.
Preparation & dosage
Ecclesiastical and folk-custom use — boxwood sprigs traditionally replace palm fronds on Palm Sunday in Central and Northern Europe ('Palmbuschen', 'palm besom'); in some regions used as grave decoration on All Saints' Day and as evergreen mourning ornament. Pure symbolism, no medicinal use.
Historical dyeing use — yellowish to red-brown natural dyes for wool and hair were formerly obtained from box leaves and roots; Pliny and Dioscorides already mention dyeing blond hair with Buxus. Today replaced by synthetic dyes; documented purely ethnobotanically.
Historical documentation only — do NOT use
These internal applications are historically documented. This plant is highly toxic — self-treatment can cause severe poisoning or death. For documentation only, explicitly NOT a recommendation.
HISTORICALLY OBSOLETE — In early modern and folk medicine of Southern and Western Europe, decoctions of box leaves were used as 'plant quinine' against malaria (intermittent fever) and as a diaphoretic. This use is now OBSOLETE and DANGEROUS: the steroid alkaloids (buxine, cyclobuxine D) cause severe gastrointestinal cramping, vomiting, diarrhoea, central nervous excitation and respiratory paralysis. Documented as ethnobotanical note only, NOT a use recommendation.
⚠ External use only
TOXIC — ALL PLANT PARTS. Buxus sempervirens contains over 100 steroid alkaloids (buxine, cyclobuxine D, buxamine, cyclobuxamine and others) belonging to the pregnane-type alkaloid group. As little as 5-15 g of leaf mass can cause severe poisoning in adults; estimated lethal dose approx. 750 g leaves in horses. Symptoms: severe vomiting, bloody diarrhoea, abdominal cramps, salivation, dizziness, convulsions, respiratory paralysis, death by central respiratory depression. In case of suspected poisoning: IMMEDIATELY call poison control. NO self-medication, NO tea infusions, NO tinctures for internal use. Honey from box flowers may also be toxic. ASPCA classification (accessed 2026-08-10): toxic to dogs. The ASPCA classifies the whole genus this way.
Strictly contraindicated. Boxwood steroid alkaloids cross the placenta; abortifacient and teratogenic effects are documented from veterinary poisoning cases in pregnant animals. External use of extensive tinctures should also be avoided.
Contraindicated. Lipophilic steroid alkaloids pass into breast milk; infants are particularly at risk due to immature hepatic metabolism. No internal use during breastfeeding.
Contraindicated. Children are particularly at risk due to low body weight and tendency to put attractive leaves and capsules in their mouth. A few leaves alone can cause severe symptoms in toddlers. Box plants in front gardens and playgrounds are problematic.
Drug interactions
Zentral dämpfende Substanzen (Benzodiazepine, Opioide, Alkohol)
Boxwood alkaloids cause central respiratory depression; combination with other respiratory depressants can lead to life-threatening apnoea.
Hepatotoxische Medikamente (Paracetamol-Hochdosis, Methotrexat, Isoniazid)
Possible additive hepatic burden through hepatic metabolism of steroid alkaloids; transaminase elevations observed in poisoning cases.
Contraindications
- Internal use in any form (tea, tincture, powder, fresh plant) — generally contraindicated due to unpredictable toxicity
- Pregnancy and breastfeeding (see above)
- Children under 18 years
- Pets (dog, cat, horse, rabbit, guinea pig, birds) — all mammals are sensitive; avoid ingestion of hedge clippings
- Existing liver disease — hepatic burden from alkaloid metabolism
Harvested part: leaves and bark
- Time of day:
- Daytime in dry weather; classical hedge clipping after the Ice Saints (May) and in late summer.
- Drying:
- Clipped material is NOT dried for medicinal purposes — use is obsolete. For decorative/floral use (palm bouquets, grave ornaments), process fresh; dispose clippings via household waste, do NOT compost when livestock is nearby.
- Storage:
- Fresh sprigs keep up to 2 weeks stored cool and humid; dried sprigs last several months as dried floristry.
- Time of day:
- Timber harvest outside the growing season (winter half-year) due to lower sap flow; trunk wood only economically usable from 60-100 years of age.
- Drying:
- Trunk sections air-dry slowly (1-2 years) in the shade to avoid cracking; final moisture 8-12 %. High raw density (~1.0 g/cm³) makes the wood extremely hard and carvable.
- Cyclobuxine DAlkaloidContent: 0.1-0.3 %Leaf
Leading steroid alkaloid of boxwood; pregnane-type skeleton with characteristic 9,10-cyclopropane bridge; main toxic agent; experimentally membrane-active and neurotoxic; basis of older pharmacological investigations.
- Buxine (Bebeerine)AlkaloidContent: 0.05-0.2 %Leaf
Historically the first named Buxus alkaloid (Faure, 1830); in older literature 'buxine' was used as a collective term for several steroid alkaloids; causes vomiting and respiratory paralysis.
- Buxamine EAlkaloidContent: Spuren - 0.05 %Leaf
Tertiary steroid alkaloid with methylamine substitution at C-3; belongs to the group of 20-aminopregnane derivatives; pharmacologically little characterized, jointly responsible for overall toxicity with other alkaloids.
- Cyclobuxamine HAlkaloidContent: Spuren - 0.05 %Leaf
Minor alkaloid with cyclopropane-bridged pregnane structure; one of the more than 100 Buxus steroid alkaloids isolated; documented in phytochemical research as structural marker.
- Buxenin GAlkaloidContent: SpurenBark
Steroid alkaloid with additional double bond; predominantly in bark and root; minor pharmacological significance; analytical marker for distinguishing Buxus species.
- BuxenonAlkaloidContent: SpurenLeaf
Ketonic steroid alkaloid; experimentally discussed as cholinesterase inhibitor; very low natural concentration.
- Gerbstoffe (Tannine)TanninContent: ca. 3-5 %Leaf
Hydrolyzable and condensed tannins in the leaves; contribute to the astringent effect of historical infusions; less toxicologically relevant than the alkaloids.
- Ätherisches Öl (Spuren)Essential oilContent: < 0.1 %Leaf
Very low content of volatile mono- and sesquiterpenes; responsible for the characteristic slightly pungent smell of freshly clipped box hedges; pharmacologically insignificant.
- [6]MonographASPCA Animal Poison Control — Boxwood (Buxus spp.)(accessed: 2026-08-10)
- [3]BookPlants for a Future — Buxus sempervirens(accessed: 2026-05-27)
- [4]BookHenriette's Herbal — Buxus sempervirens (King's American Dispensatory / historical sources)(accessed: 2026-05-27)
- [1]WikipediaGewöhnlicher Buchsbaum — Wikipedia (DE)(accessed: 2026-05-27)
- [2]WikipediaBuxus sempervirens — Wikipedia (EN)(accessed: 2026-05-27)
- [5]WikipediaCydalima perspectalis (Buchsbaumzünsler) — Wikipedia (DE)(accessed: 2026-05-27)