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Aesculus hippocastanum
Toxic🐾Gewöhnliche Rosskastanie · (Aesculus hippocastanum)
Soapberry family (Sapindaceae)
Description
Large, fan-shaped palmate leaves and upright, candle-like clusters of white to pale pink flowers characterise this deciduous tree from the soapberry family, a familiar sight along avenues and in parks across Central Europe. In autumn, spiny fruit capsules split open to reveal glossy brown seeds — the well-known conkers. These contain aescin, a mixture of triterpene glycosides that the EMA recognises as 'well-established use' in standardised extracts for the symptomatic treatment of chronic venous insufficiency. In folk practice, bark tinctures were also applied externally to swollen legs. WARNING: raw seeds, bark, leaves and roots are toxic and must never be self-extracted — only standardised commercial preparations are suitable for use; conkers are also toxic to dogs.
External use only!
This plant must NOT be taken internally. Use only as compress, salve, or bath.
CONTRAINDICATED during pregnancy
Contraindicated in pregnancy per EMA HMPC due to insufficient safety data. Aescin has shown embryotoxic properties in animal studies. No internal use during pregnancy. Topical use (gel) to be discussed with physician.
CONTRAINDICATED during breastfeeding
Contraindicated during lactation per EMA HMPC — it is unknown whether aescin passes into breast milk. Internal use not recommended. Topical application (gel on legs) only after consulting a physician.
CONTRAINDICATED for children
Standardised preparations (oral) not for children/adolescents under 18 per EMA — no safety data. Raw chestnuts are a serious poisoning risk for children (conkers in mouths). With aescin gels: avoid contact with mucous membranes and eyes, store out of reach of children.
Standardised horse chestnut seed extract (EMA well-established use) for symptomatic treatment of chronic venous insufficiency — lead compound aescin.
Preparation & dosage
STANDARDISED SEED EXTRACT (EMA well-established use): Standardised dry extracts of horse chestnut seed, calculated as 16–20 % triterpene glycosides (aescin) (e.g. AESCORIN forte, Venostasin retard, horse chestnut extract capsules), DER 4–7:1. Daily dose 100 mg aescin, split into 2 doses (morning and evening), preferably with meals and sufficient fluid. Sustained-release formulations preferred over immediate-release (better tolerability). Indication: symptomatic treatment of chronic venous insufficiency (CVI) — leg oedema, heaviness, pain, pruritus, nocturnal calf cramps. Effect onset after 4–8 weeks of regular use. CAUTION: Raw seeds are toxic — use only standardised finished preparations, NEVER self-extract.
- Liquid amount
- 1–3 ml
- Doses per day
- 2×
- Max duration
- 12 weeks
⚠ Age restriction: ≥ 18 years — Per EMA, adults only — insufficient safety data for children/adolescents under 18.
Topical aescin gel or bark compress for venous insufficiency, leg oedema and tired, heavy legs.
Preparation & dosage
TOPICAL APPLICATION (standardised gel/cream): Finished vein gels or creams with 2 % aescin applied 2–3× daily to affected leg areas (lower leg, ankle), massaged gently towards the heart. Do not apply to open wounds or mucous membranes. Traditionally also as a compress with boiled, cooled bark decoction (1:20, simmer 10 min) on swollen, tired legs — soak cloth in liquid, apply for 15–20 min. Regular use over several weeks is recommended.
Folk bark tincture for topical application to swollen legs and varicosities; internal use not recommended.
Preparation & dosage
BARK TINCTURE (folk, external only): Young branch bark strips (spring, before leaves fully open) macerated 1:5 in 40–60 % ethanol for 2–4 weeks, filtered. Apply undiluted to tired, swollen legs 2× daily as a rub. Traditionally used for haemorrhoids as salve or suppository base. Internal use of bark tincture NOT recommended — insufficient standardisation, no safety data, potentially toxic.
- Liquid amount
- 2–5 ml
- Doses per day
- 2×
- Max duration
- 4 weeks
Traditional foot or full bath from chestnut decoction for varicose veins, venous congestion and tired, swollen legs.
Preparation & dosage
FOOT BATH / FULL BATH (traditional): For a footbath, simmer 4–6 crushed raw or dried horse chestnuts (shells removed) in 1 L water for 20 minutes (decoction), strain, add to footbath tub and fill to ~10 L with warm water (38–40 °C). Foot soak for 15–20 min. For a full bath, scale decoction from 20–30 chestnuts. Traditionally for varicose veins, tired legs, haemorrhoids (sitz bath). Traditional use — not a substitute for standardised extract. Discard chestnuts after bathing, do not process or eat them.
Aescin-containing vein creams and gels (Kommission E, positive) for topical treatment of CVI, haemorrhoids and bruising.
Preparation & dosage
AESCIN SALVE / VEIN OIL (Kommission E): Finished preparations containing 2 % aescin (gel, cream, lotion) applied 2–3× daily to the affected skin area. Massage gently — direction from distal to proximal (ankle → knee → thigh) to support lymph and venous return. Use adjunctively with compression stockings (additive effect on oedema reduction). Own preparation: 1–2 % aescin dry extract in shea butter/beeswax base — only with PHARMACEUTICAL-GRADE aescin, never self-extract from raw chestnuts.
Folk flower compress for swollen joints, bruising and overexerted muscles.
Preparation & dosage
FLOWER COMPRESS (folk): 2–3 tbsp fresh or dried horse chestnut flowers in 500 ml hot water, steep 15 min, strain, cool to skin temperature. Soak a clean cloth and apply as a wet compress on swollen joints or bruises (20–30 min). Folk use also for muscle soreness after physical exertion. Evidence purely empirical — no clinical studies on flower compresses.
Historical documentation only — do NOT use
These internal applications are historically documented. This plant is highly toxic — self-treatment can cause severe poisoning or death. For documentation only, explicitly NOT a recommendation.
Folk leaf tea for cold complaints, fever and as spring tonic — no standardised medical application.
Preparation & dosage
LEAF TEA (folk): 1–2 tsp dried finely cut horse chestnut leaves in 250 ml boiling water, steep covered 10 min, strain. Up to 2 cups daily. Folk use for fever, catarrh, cold complaints and as 'blood-purifying' spring tea. NO adequate scientific evidence — adjunctive folk use only. Leaves contain coumarins and flavonoids but are not standardised for therapeutic purposes. For persistent complaints beyond 2 weeks: medical evaluation.
- Dry amount
- 1–2 g
- Doses per day
- 2×
- Max duration
- 2 weeks
Phytotherapeutic seed liquid extracts as finished preparation for CVI — standardised products only, no self-extraction.
Preparation & dosage
PHYTOTHERAPEUTIC TINCTURE (finished preparation only!): Liquid extracts and tinctures of horse chestnut seed (e.g. Aesculuforce, Arkocaps) as finished products with defined aescin content (typically 1.5–3 mg aescin/ml). 1–2 ml 3× daily with water. Self-made seed tinctures are NOT safe — aescin content and toxicity uncontrollable. Use in adults only, after exclusion of deep vein thrombosis. No continuous use beyond 8 weeks without medical supervision.
- Liquid amount
- 1–2 ml
- Doses per day
- 3×
- Max duration
- 8 weeks
⚠ Age restriction: ≥ 18 years — Adults only. Not recommended for children under 18 per EMA.
⚠ External use only
CRITICAL: Raw horse chestnut seeds (conkers), bark, leaves and roots are TOXIC — contain toxic saponins (mainly protoaescigenin after hydrolysis) and glucosides. Poisoning symptoms: nausea, vomiting, diarrhoea, dizziness, muscle twitching, in severe cases paralysis. Standardised finished preparations (tablets, capsules, gels) are safe when used as directed. NEVER attempt self-extraction. With deep vein thrombosis: standard preparations are NO substitute for anticoagulants — see doctor immediately. With acute leg oedema with redness, warmth and pain (suspected DVT) → emergency room, no aescin extract instead of evaluation. Children: poisoning risk from playing with horse chestnuts — conkers in mouths can be toxic. Animal warning: toxic to dogs (ASPCA warning). ASPCA classification (accessed 2026-08-10): toxic to dogs and cats. The ASPCA classifies the whole genus this way.
⏱ Max continuous use: 12 weeks
Contraindicated in pregnancy per EMA HMPC due to insufficient safety data. Aescin has shown embryotoxic properties in animal studies. No internal use during pregnancy. Topical use (gel) to be discussed with physician.
Contraindicated during lactation per EMA HMPC — it is unknown whether aescin passes into breast milk. Internal use not recommended. Topical application (gel on legs) only after consulting a physician.
Standardised preparations (oral) not for children/adolescents under 18 per EMA — no safety data. Raw chestnuts are a serious poisoning risk for children (conkers in mouths). With aescin gels: avoid contact with mucous membranes and eyes, store out of reach of children.
Drug interactions
Antikoagulantien (Warfarin, Phenprocoumon, Acenocoumarol)
Aescin may inhibit platelet aggregation and potentially enhance the anticoagulant effect of coumarin derivatives. Increased bleeding risk. INR monitoring when starting or stopping horse chestnut preparations. Clinically rarely documented but theoretically relevant.
Thrombozytenaggregationshemmer (ASS, Clopidogrel, Ticagrelor)
Additive platelet inhibitory effect possible — increased bleeding risk when combined with aescin extracts. Combination only under medical supervision.
Nephrotoxische Arzneimittel (NSAR, Aminoglykoside, Cisplatin)
Aescin is nephrotoxic at high doses (proximal tubular injury). Combination with other nephrotoxic substances increases the risk of renal damage. Monitor renal function.
Antidiabetika (Insulin, Metformin, Sulfonylharnstoffe)
Isolated reports of blood-glucose-lowering effect of horse chestnut extracts in vitro. Theoretical risk of additive hypoglycaemia with concurrent antidiabetic medication. Monitor blood glucose.
Contraindications
- Hypersensitivity to Aesculus hippocastanum or its constituents (incl. aescin hypersensitivity — may manifest as urticaria or pruritus).
- Severe renal insufficiency (aescin nephrotoxic at high doses; cautious dosing with mild-to-moderate impairment).
- Deep vein thrombosis (DVT) or acute venous inflammation — no aescin extract as substitute for medical treatment.
- Pregnancy and lactation (internal use, contraindicated per EMA HMPC).
- Children and adolescents under 18 for oral standardised preparations.
Harvested part: ripe seeds (autumn)
- Time of day:
- After rain periods or in the morning when the spiny case has already split open and the glossy brown seed has fallen out. Collect fresh from the ground, not from paths where dogs walk. Only fully ripe, firm, uniformly brown seeds — discard shrivelled, mouldy or insect-damaged ones.
- Drying:
- IMPORTANT: Horse chestnut seeds are NOT dried and processed at home for pharmaceutical purposes — standardisation of aescin concentration is only possible industrially. For scientific/documentary purposes: remove shell, slice cotyledons thinly, dry in dehydrator at 40 °C for 24–36 h until brittle-hard. Store dried material in airtight glass, cool and dark. NO therapeutic self-preparation — purchase only standardised commercial products.
- Storage:
- 12 months — Fresh chestnuts keep for 2–4 weeks in a cool, airy place. Dried slices (documentation purposes only) airtight, dark, max 1 year. For therapeutic use: only tested finished preparations with expiry date.
- Time of day:
- On dry mornings (10–13 h), after dew has evaporated. Harvest the flower panicles only when white flowers are fully open (mid-bloom) — buds contain fewer flavonoids. Carefully cut individual flower panicles without damaging branches.
- Drying:
- Spread flowers immediately after harvesting in a single layer on gauze or sieves, dry in shade at max 35 °C with good air circulation. Harvest window: 7–14 days (full bloom). Separate fully dried flowers from thick stems, store in dark jars or paper bags. Use: flower compresses (folk), not for standardised pharmaceutical preparations.
- Storage:
- 12 months — Airtight, dark, cool. Use within 12 months. Discard if browning or unpleasant smell develops.
- Aescin (Escin) — Triterpenglykosid-Gemisch (alpha- und beta-Aescin)SaponinContent: 3-6 %Seed
Lead compound of horse chestnut seeds — a mixture of approximately 30 triterpene saponins based on protoaescigenin and barringtogenol C as aglycones. Main mechanism: reduction of capillary hyperpermeability via inhibition of hyaluronidase and elastase; antiexudative and antiphlogistic action. Basis for EMA standardisation (16–20 % total aescin in dry extract). Raw: toxic — vomiting, haemolysis; hydrolysis to protoaescigenin increases toxicity.
- Flavonoide (Quercetin-3,7-Dirhamnosid, Isoquercitrin, Rutin, Kaempferol-Glykoside)FlavonoidContent: 0.5-1.5 %Leaf
Predominantly in leaves and flowers. Antioxidant and capillary-protective action; complement the anti-oedematous effect of aescin. Quercetin glycosides contribute to vascular wall integrity.
- Cumarine (Aesculin, Fraxin, Scopolin)OtherContent: 0.3-1.3 %Bark
Mainly aesculin (6,7-dihydroxycoumarin-6-glucoside) and fraxin, especially in the bark. Aesculin shows UV-absorbing, mildly anticoagulant and anti-inflammatory properties. Up to 1.3 % in bark; only traces in seeds. Historically used as a venous therapeutic; now superseded by standardised seed extract.
- Gerbstoffe / Kondensierte Tannine (Catechine, Procyanidine)TanninContent: 1-5 %Bark
Condensed tannins, especially in the bark. Astringent action on mucous membranes and skin, mildly haemostatic. Contribute to the traditional use of bark for diarrhoea and haemorrhoids. Lower concentrations in seeds.
- Stärke (Amylose und Amylopektin)PolysaccharideContent: 40-60 %Seed
Main constituent of horse chestnut seed (dry weight). Not therapeutically relevant, but explains the floury texture of the cotyledons. Horse chestnut starch is not edible for humans due to aescin content (unlike sweet chestnut starch).
- Fette Öle und Fettsäuren (Palmitinsäure, Stearinsäure, Ölsäure, Linolsäure)OtherContent: 5-8 %Seed
Fixed oils in the seed cotyledons, ~5–8 % of dry weight. Not nutritionally usable by humans (raw toxic). Largely separated during extraction of crude fibre.
- Phytosterole (beta-Sitosterol, Stigmasterol)OtherContent: 0.1-0.3 %Seed
Plant sterols with anti-inflammatory and membrane-stabilising properties. Trace amounts in seeds and bark. May contribute to the overall antiexudative effect.
- Proanthocyanidine (oligomere Procyanidine, B-Typ)TanninContent: 0.5-2 %Seed
Oligomeric catechin/epicatechin condensates (similar to grape seed). Antioxidant, capillary-protective and mildly vasotonous. Synergistically complement the anti-oedematous effect of aescin. Concentration varies by growing region and harvest maturity.
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